Registration Dossier
Registration Dossier
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EC number: 211-020-6 | CAS number: 627-93-0
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- read-across based on grouping of substances (category approach)
- Adequacy of study:
- key study
- Study period:
- March-May 2010
- Reliability:
- 1 (reliable without restriction)
- Justification for type of information:
- This IUCLID for dimethyl adipate is compiled using data from the substance itself, a structurally related compound (dimethyl glutarate) and a mixture of dibasic esters (dimethyl adipate, succinate and glutarate). The phys-chem properties of each of these substances are similar and the document attached justifies why data on the category members can be used to support the data gaps for dimethyl adipate.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
- Water solubility:
- 4 g/L
- Temp.:
- 20 °C
- pH:
- 3.5
- Conclusions:
- Interpretation of results (migrated information): soluble (1000-10000 mg/L)
The water solubility of dimethyl adipate is 4.0 g/L at 20°C. - Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 2012
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Principles of method if other than guideline:
- Dimethyl adipate aliquots (0.5 g) were added progressively to 100 water at a constant temperature of 20 °C; the solution was stirred several minutes between each addition and the turbidity of the solution was evaluated visually.
- GLP compliance:
- no
- Type of method:
- other: visual turbidimetry
- Water solubility:
- > 25 - <= 30 g/L
- Temp.:
- 20 °C
- Remarks on result:
- other: The pH of the substance was not measured, but we know by experience that the pH of dimethyl adipate is slightly basic and for a non ionizable substance like this one, the pH is not an important factor.
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 2000
- Reliability:
- 3 (not reliable)
- Guideline:
- other: not known
- Principles of method if other than guideline:
- Not known
- GLP compliance:
- not specified
- Type of method:
- other: not known
- Water solubility:
- 29.9 g/L
- Temp.:
- 20 °C
- pH:
- 8.9
Referenceopen allclose all
Description of key information
The solubility of dimethyl adipate is 4 g/l at 20 °C.
Key value for chemical safety assessment
- Water solubility:
- 4 g/L
- at the temperature of:
- 20 °C
Additional information
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