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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Physical & Chemical properties

Dissociation constant

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dissociation constant
Data waiving:
study scientifically not necessary / other information available
Justification for data waiving:
the study does not need to be conducted because the substance is hydrolytically unstable (half-life less than 12 hours)

Description of key information

Dissociation constant [3-chloropropyl(dimethoxy)methylsilane]: Not relevant due to rapid hydrolysis in water

Dissociation constant [(3-chloropropyl)(methyl)silanediol]: approximately 12

Key value for chemical safety assessment

Additional information

The requirement to test the substance for dissociation constant is waived because in contact with water the substance hydrolyses rapidly. The hydrolysis products in this case are 3-chloropropyl(methyl)silanediol and methanol.

There are no reliable measured data for the dissociation constant of 3-chloropropyl(methyl)silanediol. The typical dissociation constants for the hydroxyl protons of silanediols are available from studies in other silanediols. It is appropriate to read-across dissociation constant data for 3-chloropropyl(methyl)silanediol from dimethylsilanediol. This suggests that silanols are not expected to undergo significant dissociation within the range of pH relevant in the environment or in vivo.

Dimethylsilanediol is reported in a secondary source to have a first dissociation constant of 11.9. Additional information is given in a supporting report (PFA 2013b) attached in Section 13.


PFA (2013b). Peter Fisk Associates, Dissociation constant Analogue report. PFA.300.001.001.