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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Skin sensitisation

Currently viewing:

Administrative data

Endpoint:
skin sensitisation: in vivo (non-LLNA)
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
other: Body responsible for the test
Title:
Unnamed
Year:
2011

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
EU Method B.6 (Skin Sensitisation)
GLP compliance:
yes
Type of study:
guinea pig maximisation test
Justification for non-LLNA method:
not available

Test material

Constituent 1
Chemical structure
Reference substance name:
N,N',N'',N'''-tetrakis(4,6-bis(butyl-(N-methyl-2,2,6,6-tetramethylpiperidin-4-yl)amino)triazin-2-yl)-4,7-diazadecane-1,10-diamine
EC Number:
401-990-0
EC Name:
N,N',N'',N'''-tetrakis(4,6-bis(butyl-(N-methyl-2,2,6,6-tetramethylpiperidin-4-yl)amino)triazin-2-yl)-4,7-diazadecane-1,10-diamine
Cas Number:
106990-43-6
Molecular formula:
C132 H250 N32
IUPAC Name:
N2-[2-({4,6-bis[butyl(1,2,2,6,6-pentamethylpiperidin-4-yl)amino]-1,3,5-triazin-2-yl}[3-({4,6-bis[butyl(1,2,2,6,6-pentamethylpiperidin-4-yl)amino]-1,3,5-triazin-2-yl}amino)propyl]amino)ethyl]-N2-[3-({4,6-bis[butyl(1,2,2,6,6-pentamethylpiperidin-4-yl)amino]-1,3,5-triazin-2-yl}amino)propyl]-N4,N6-dibutyl-N4,N6-bis(1,2,2,6,6-pentamethylpiperidin-4-yl)-1,3,5-triazine-2,4,6-triamine

In vivo test system

Test animals

Species:
guinea pig
Strain:
other: albino guinea pig (Pirbright white strain DHP)
Sex:
not specified

Study design: in vivo (non-LLNA)

Inductionopen allclose all
Route:
intradermal and epicutaneous
Vehicle:
other: vaseline
Concentration / amount:
First induction (intradermal injection): 1 % in sesame oil and adjuvant mixture
Second induction (epidermal application): 10 % in vaseline
Concentration of test material and vehicle used for each challenge: 0.3 % in vaseline
Challenge
Concentration / amount:
First induction (intradermal injection): 1 % in sesame oil and adjuvant mixture
Second induction (epidermal application): 10 % in vaseline
Concentration of test material and vehicle used for each challenge: 0.3 % in vaseline
No. of animals per dose:
Number of animals in test group: 20
Number of animals in negative control group: 10

Results and discussion

In vivo (non-LLNA)

Resultsopen allclose all
Reading:
other: no data
Group:
test chemical
Dose level:
0.3 %
No. with + reactions:
12
Total no. in group:
20
Clinical observations:
no data
Remarks on result:
other: Reading: other: no data. Group: test group. Dose level: 0.3 %. No with. + reactions: 12.0. Total no. in groups: 20.0. Clinical observations: no data.
Reading:
other: no data
Group:
test chemical
Dose level:
0.3 %
No. with + reactions:
15
Total no. in group:
20
Clinical observations:
no data
Remarks on result:
other: Reading: other: no data. Group: test group. Dose level: 0.3 %. No with. + reactions: 15.0. Total no. in groups: 20.0. Clinical observations: no data.

Any other information on results incl. tables

Data incomplete.

Applicant's summary and conclusion

Interpretation of results:
sensitising
Remarks:
Migrated information Criteria used for interpretation of results: EU