Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 216-333-1 | CAS number: 1560-69-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2011-05-17 to 2011-06-01
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 011
- Report date:
- 2011
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Version / remarks:
- 2002-04-24
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- Cobalt(2+) propionate
- EC Number:
- 216-333-1
- EC Name:
- Cobalt(2+) propionate
- Cas Number:
- 1560-69-6
- Molecular formula:
- C3H6O2.1/2Co
- IUPAC Name:
- cobalt(2+) dipropanoate
- Details on test material:
- - Name of test material (as cited in study report): Cobalt propionate
- Physical state: slight purple/blue powder
- Storage condition of test material: store in a cool, well-ventilated place away from incompatible materials. At room temperature (20 ± 5 °C, provided by Harlan Laboratories Ltd.)
- Stability of test Item: stable under storage conditions.
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: Harlan Laboratories U.K. Ltd., Hillcrest, Dodgeford Lane, Belton, Loughborough, Leics, LE12 9TE / UK
- Age at study initiation: 11 weeks (male); 10 - 11 weeks (female)
- Weight at study initiation: 2775 g (male); 2864 - 3244 g (females)
- Housing: individually in stainless steel cages
- Diet (ad libitum): pelleted standard Teklad Global High Fiber Rabbit Diet 2031C (batch no. 80/10, Provimi Kliba AG, 4303 Kaiseraugst / Switzerland). A piece of wood (batch no. 122201, imported by Indulab AG, Gams / Switzerland from ABEDD® - LAB & VET GmbH, 1160 Vienna / Austria) and a haystick 4642 (batch no. 37/10, Provimi Kliba AG, 4303 Kaiseraugst / Switzerland) were also provided for environmental enrichment.
- Water (ad libitum): community tap water from Füllinsdorf
- Acclimation period: five to 6 days under laboratory conditions after health examination. Only animals without any visual signs of illness were used for the study.
ENVIRONMENTAL CONDITIONS
- Temperature: 17-23 °C
- Relative humidity: 30-70%
- Air changes: 10-15 air changes per hour
- Photoperiod (hrs dark / hrs light): 12/12 (music played during the daytime light period)
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): the test item was applied as a weight of 0.1 g/animal. The test item was applied to the conjunctival sac of the left eye of each animal after gently pulling the lower lid away from the eyeball. The lids were then gently held together for about one second to prevent loss of test item. The right eye remained untreated and served as the reference control. - Duration of treatment / exposure:
- not applicable
- Observation period (in vivo):
- approximately 1, 24, 48 and 72 hours as well as 7, 10 and 14 days after administration
- Number of animals or in vitro replicates:
- 1 male rabbits / 2 female rabbits
(a single animal (the male) was treated first. As neither a corrosive effect nor a severe irritant effect was observed after the 1- and 24-hour examinations, the test was completed using the two remaining animals.) - Details on study design:
- The eyes of the animals were examined one day prior to test item administration.
SCORING SYSTEM: according to the Draize scale
Scleral reddening and ocular discharge were also assessed (scale for assessment can be seen in the field "Any other information on materials and methods incl. tables" below).
TOOL USED TO ASSESS SCORE:
Eye examinations were made with a Varta Cliptrix diagnostic-lamp (Roth AG, 4153 Reinach / Switzerland).
OBSERVATIONS
- Viability / Mortality: daily from acclimatization of the animals to the end of the observation period.
- Clinical Signs (systemic): daily from acclimatization of the animals to the end of the observation period.
- Body Weights: at start of acclimatization, on the day of application and at the end of tbe observation period.
- Pathology: no necropsy was performed on the animals sacrificed at termination of observation.
The animals were sacrificed by intravenous injection of 1.0 mL/kg body weight of a solution of 162 mg/mL sodium pentobarbitone into the ear vein and discarded.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Remarks:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- iris score
- Basis:
- mean
- Remarks:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 2
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Remarks:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 1.67
- Max. score:
- 3
- Reversibility:
- fully reversible within: 7 days
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Remarks:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Remarks:
- animal #2
- Time point:
- other: 24, 48 and 72 hours
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- iris score
- Basis:
- mean
- Remarks:
- animal #1
- Time point:
- other: 24, 48 and 72 hours
- Score:
- 0
- Max. score:
- 2
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Remarks:
- animal #2
- Time point:
- other: 24, 48 and 72 hours
- Score:
- 2.33
- Max. score:
- 3
- Reversibility:
- not fully reversible within: 14 days
- Remarks on result:
- other: The animal was further affected up to at least 14 days after treatment.The ocular findings consisted of scleral and conjunctival reddening as well as discharge (with mucus) and were considered as being a secondary effect (infection).
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Remarks:
- animal #2
- Time point:
- other: 24, 48 and 72 hours
- Score:
- 0.33
- Max. score:
- 4
- Reversibility:
- fully reversible within: 48 hours
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Remarks:
- animal #3
- Time point:
- other: 24, 48 and 72 hours
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- iris score
- Basis:
- mean
- Remarks:
- animal #3
- Time point:
- other: 24, 48 and 72 hours
- Score:
- 0
- Max. score:
- 2
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Remarks:
- animal #3
- Time point:
- other: 24, 48 and 72 hours
- Score:
- 2
- Max. score:
- 3
- Reversibility:
- fully reversible within: 7 days
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Remarks:
- animal #3
- Time point:
- other: 24, 48 and 72 hours
- Score:
- 0
- Max. score:
- 4
- Irritant / corrosive response data:
- The instillation of cobalt propionate into the eye resulted in marked reddening of the conjunctivae in all animals 1 hour after treatment and persisted in all animals as slight to marked reddening until 72 hours after treatment. Slight to obvious swelling of the conjunctivae was noted in all animals 1 hour after treatment and persisted as slight in one female 24 hours later. Marked reddening of the sclerae was seen in all three animals 1 hour after treatment. The severity of the reddening decreased and was still present as slight 48 hours after treatment in all animals. One female was still affected with a slight reddening of the sclerae at the 72 hours. Ocular discharge appeared in both females at the 1-hour reading. These effects were reversible and were no longer evident 7 days after treatment in the male and one female.
One female was further affected up to at least 14 days after treatment. The ocular findings consisted of scleral and conjunctival reddening as well as discharge (with mucus) and were considered as being a secondary effect (infection). The local findings observed from 7 days after treatment were located at the corner of the treated eye (from the nictitating membrane side) and first appeared as reddened. Ten days after treatment, the reddening was still present, with
discharge (and mucus). The corner of the eye appeared purulent 12 days after treatment. By removing the pus, the affected site was reddened. The next observation was done 14 days after treatment and again a purulent area with reddening and discharge (with mucus) were seen. As these findings were considered as being a secondary effect (infection), the study was closed thereafter.
No abnormal findings were observed for the cornea or for the iris light reflex. No corrosion was observed. No staining of the treated eyes by the test item was observed. No test item remnants were observed. - Other effects:
- - Viability / Mortality: no intercurrent deaths occurred during the course of the study.
- Clinical Signs: no clinical signs were recorded throughout the entire observation period.
- Body weights: the body weights were within the range commonly recorded for this strain and age.
- Pathology: no necropsy was performed at the end of the study.
Applicant's summary and conclusion
- Interpretation of results:
- Category 2 (irritating to eyes) based on GHS criteria
- Conclusions:
- Cobalt propionate is considered to be an eye irritant.
According to the EC Regulation No. 1272/2008 and subsequent regulations, the test item is classified as Category 2.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.