Registration Dossier
Registration Dossier
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EC number: 204-662-3 | CAS number: 123-92-2
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- disregarded due to major methodological deficiencies
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: Deficiencies in details about tested material and methodology. Only few animals have taken part in study. The study is not performed according to an acknowledged standard method.
Data source
Materials and methods
- Principles of method if other than guideline:
- subcutaneous injection of test substance and subsequent examination of behaviour, physiological effects and organs
- GLP compliance:
- no
Test material
- Reference substance name:
- Isopentyl acetate
- EC Number:
- 204-662-3
- EC Name:
- Isopentyl acetate
- Cas Number:
- 123-92-2
- Molecular formula:
- C7H14O2
- IUPAC Name:
- 3-methylbutan-1-ol
- Details on test material:
- The degree of purity and composition of "isoamyl acetate (IAA)" (term as stated in the abstract) is unclear. No information is given on the content of other pentyl acetate isomers.
Constituent 1
Test animals
- Species:
- other: cat and guinea pig
- Sex:
- not specified
Administration / exposure
- Route of administration:
- subcutaneous
- Vehicle:
- not specified
Results and discussion
Any other information on results incl. tables
Results:
| Animal species | Applied dose subcutaneous per body weight of animal (g/kg) | Effects |
| cat | 3 | Animal not fully conscious but recovering. Killed after 12 days. Body examination: nutmeg liver, other organs without any particularities |
| cat | 3 | Animal not fully conscious but recovering. Killed after 6 days. Body examination: no particularities found |
| guinea pig | 1 | survived |
| guinea pig | 3 | survived |
| guinea pig | 5 | After 1/2 hour deep narcosis, thereafter rear extremities paralysed. Death after 6 days. |
Conclusion: The lethal dose in a guinea pig was 5000 mg/kg body weight. Supposedly this result was obtained from testing a single animal.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
