Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
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EC number: 203-809-9 | CAS number: 110-86-1
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Experimental study in a reputable industry laboratory which precedes establishment of guideline and GLP.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 978
- Report date:
- 1978
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Precedes establishment of guideline and GLP. It is assumed that this scientific study was performed according to the accepted standards of its day.
- GLP compliance:
- no
Test material
- Reference substance name:
- Pyridine
- EC Number:
- 203-809-9
- EC Name:
- Pyridine
- Cas Number:
- 110-86-1
- Molecular formula:
- C5H5N
- IUPAC Name:
- pyridine
Constituent 1
Test animals / tissue source
- Species:
- rabbit
Test system
- Amount / concentration applied:
- no data provided in summary
- Duration of treatment / exposure:
- no data provided in summary
- Number of animals or in vitro replicates:
- no data provided in summary
Results and discussion
In vivo
Results
- Irritation parameter:
- other: qualitative
- Basis:
- mean
- Remarks on result:
- other: Moderate irritation
- Irritant / corrosive response data:
- Moderately severe injury with corneal damage was observed in the guinea pig.
Applicant's summary and conclusion
- Interpretation of results:
- moderately irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: expert judgment
- Conclusions:
- Pyridine was evaluated as a moderate eye irritant with corneal damage in rabbits.
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