Registration Dossier
Registration Dossier
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EC number: 203-809-9 | CAS number: 110-86-1
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation / corrosion
- Remarks:
- other:
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable data but article lacks detail.
Data source
Reference
- Reference Type:
- publication
- Title:
- Acute Toxicity and Skin Corrosion Data for Some Organic and Inorganic Compounds and Aqueous Solutions
- Author:
- Vernot, E. H., J. D. MacEwen, C. C. Haun and E. R. Kinkead
- Year:
- 1 977
- Bibliographic source:
- Toxicol. Appl. Pharmacol. 42:417 - 423
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- acceptable methods, 4 h, on intact and abraded, clipped skin of rabbits.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Pyridine
- EC Number:
- 203-809-9
- EC Name:
- Pyridine
- Cas Number:
- 110-86-1
- Molecular formula:
- C5H5N
- IUPAC Name:
- pyridine
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- other: intact and abraded, clipped skin
- Vehicle:
- unchanged (no vehicle)
- Duration of treatment / exposure:
- 4 h
- Observation period:
- 24 and 72 h
- Number of animals:
- 3 rabbits
- Details on study design:
- One half milliliter of undiluted pyridine was applied to intact and abraded skin of female albino rabbits
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Time point:
- other: 24 and 72 h
- Reversibility:
- not reversible
- Remarks:
- Corrosive
Any other information on results incl. tables
Irreversible damage to the skin occurred at both 24 and 48 hours after a 4 hour exposure of intact skin to pyridine.
Applicant's summary and conclusion
- Interpretation of results:
- corrosive
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Pyridine, applied undiluted to intact and abraded rabbit skin, was corrosive at 24 and 72 hours.
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