Registration Dossier
Registration Dossier
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EC number: 202-992-2 | CAS number: 101-96-2
Repeated dose toxicity: dermal
Administrative data
- Endpoint:
- short-term repeated dose toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Only secondary source available. No data on test protocol.
Data source
Reference
- Reference Type:
- secondary source
- Title:
- Toxicological Evaluations 12 - Potential Health Hazards of Existing Chemicals.
- Author:
- BG Chemie
- Bibliographic source:
- Toxicological Evaluations, volume 12, section "N,N'-di-sec-butyl-p-phenylenediamine", p. 193-203. Published by Springer.
Materials and methods
- Limit test:
- yes
Test material
- Reference substance name:
- N,N'-di-sec-butyl-p-phenylenediamine
- EC Number:
- 202-992-2
- EC Name:
- N,N'-di-sec-butyl-p-phenylenediamine
- Cas Number:
- 101-96-2
- Molecular formula:
- C14H24N2
- IUPAC Name:
- N,N'-di-sec-butyl-p-phenylenediamine
- Details on test material:
- technical grade
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- not specified
- Details on exposure:
- clipped dorsal skin
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- 2 weeks
- Frequency of treatment:
- 5 days / week
Doses / concentrations
- Remarks:
- Doses / Concentrations:
90 mg / kg bw
Basis:
nominal per unit body weight
- No. of animals per sex per dose:
- 3 male rats
- Control animals:
- yes
Results and discussion
Results of examinations
- Clinical signs:
- no effects observed
- Dermal irritation:
- effects observed, treatment-related
- Description (incidence and severity):
- irritant effects and ulceration of the skin
- Mortality:
- no mortality observed
- Details on results:
- No changes in haematological parameters other than granulocytosis were observed in the treated rats compared with 3 control rats.
The methaemoglobin level was not increased.
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
