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Environmental fate & pathways

Bioaccumulation: aquatic / sediment

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Reference
Endpoint:
bioaccumulation in aquatic species: fish
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 305 (Bioconcentration: Flow-through Fish Test)
Deviations:
no
GLP compliance:
yes
Radiolabelling:
not specified
Vehicle:
no
Test organisms (species):
other: carp
Details on test organisms:
TEST ORGANISM

Common name: Carp
Length at study initiation (length definition, mean, range and SD): 3 - 5 cm
Weight at study initiation (mean and range, SD): 3 g
Method of breeding: SOP/HBS/027
Route of exposure:
aqueous
Test type:
flow-through
Water / sediment media type:
natural water: freshwater
Total exposure / uptake duration:
28 d
Test temperature:
24.1 - 25.0°C
pH:
7.3 - 7.7
Dissolved oxygen:
7.0 - 8.2 mg/L
Nominal and measured concentrations:
4 µg/L, 40 µg/L
Reference substance (positive control):
no
Type:
BCF
Value:
< 41.7 dimensionless
Basis:
whole body w.w.
Time of plateau:
28 d
Calculation basis:
steady state
Remarks on result:
other: Conc.in environment / dose:3.84 µg/L
Type:
BCF
Value:
< 4.2 dimensionless
Basis:
whole body w.w.
Time of plateau:
28 d
Calculation basis:
steady state
Remarks on result:
other: Conc.in environment / dose:38.5 µg/L
Validity criteria fulfilled:
not specified
Conclusions:
The BCF of the test material was < 41.7 at a concentration of 3.84 µg/l, and < 4.2 at a concentration of 38.5 µg/L.
Executive summary:

The aquatic bioaccumulation of the test substance was determined in accordance with the OECD Guideline for Testing of Chemicals 305. The aquatic bioaccumulation was measured in a flow-through fish test, using carp, to assess the bioconcentration in fish. The fish was exposed to the test substance at concentrations of 3.84 µg/L and 38.5 µg/L in flow-through test conditions at 24.1°C-25.0°C for 28 days. The BCF was found to be < 41.7 at 3.84 µg/L and < 4.2 at 38.5 µg/L.

Description of key information

The BCF of the test substance was found to be < 41.7 at a concentration of 3.84 µg/L, and < 4.2 at a concentration of 38.5 µg/L.

Key value for chemical safety assessment

BCF (aquatic species):
4.2 dimensionless

Additional information

A study was conducted to assess the aquatic bioaccumulation of the test substance. The study is considered reliable as it was conducted on the registered substance according to OECD Testing Guideline 305. The BCF of the test substance was found to be < 41.7 at a concentration of 3.84 µg/L, and < 4.2 at a concentration of 38.5 µg/L.