Registration Dossier
Registration Dossier
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EC number: 237-158-7 | CAS number: 13674-84-5
Neurotoxicity
Administrative data
- Endpoint:
- neurotoxicity: acute oral
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 000
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: USA EPA proposed guideline for acute delayed neurotoxicity FR43(163):37362-37363,1978
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Tris(2-chloro-1-methylethyl) phosphate
- EC Number:
- 237-158-7
- EC Name:
- Tris(2-chloro-1-methylethyl) phosphate
- Cas Number:
- 13674-84-5
- Molecular formula:
- C9H18Cl3O4P
- IUPAC Name:
- tris(2-chloro-1-methylethyl) phosphate
Constituent 1
Test animals
- Species:
- hen
- Strain:
- other: white leghorn hen
- Sex:
- not specified
Administration / exposure
- Route of administration:
- oral: feed
- Vehicle:
- corn oil
- Duration of treatment / exposure:
- No data.
- Frequency of treatment:
- Two doses (10ml/kg each) were administered orally to hens 21 days apart.
Doses / concentrations
- Remarks:
- Doses / Concentrations:
10ml/kg
Basis:
no data
- No. of animals per sex per dose:
- 18 animals per dose
- Control animals:
- yes
- Details on study design:
- The study has positive and negative control
positive control: TOCP
negative control: corn oil
Results and discussion
Results of examinations
- Details on results:
- No inhibit either plasma and cholinesterase or brain neurotoxic esterase 24 hours after dosing.
No motor impairment observed to compare with that seen in TOCP group.
Applicant's summary and conclusion
- Conclusions:
- No evidence of delayed neurotoxicity was noted.
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