Registration Dossier
Registration Dossier
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EC number: 271-231-4 | CAS number: 68526-83-0
Long-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
A chronic EC10 > 0.28 mg/L (Upper Threshold Concentration) for Pimephales promelas (OECD 210, flow-through) exposed to Alcohols, C7-9-iso, C8-rich.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 0.28 mg/L
Additional information
A preliminary exposure assessment using information from long-term test results with daphnids and algae indicated a need to investigate further the effects on aquatic organisms (RCRs to the water compartments were not well below 1 for all the supported uses; i.e., formulation, industrial intermediates and coatings).
A limit test, at the upper threshold concentration (UTC: defined as the lowest of two effect concentrations obtained for algae and daphnids; 0.28 mg/L for the registered substance) was performed and no adverse effects were observed (based on hatch, survival, weight and length). As such, the chronic fish toxicity result is reported as greater than the UTC value.
Experimental long-term toxicity data for the registered substance are adequate for the purpose of classification and labelling and/or risk assessment. Supporting information is provided by acute and chronic aquatic toxicity values calculated using the neutral organics structure-activity relationship in the ECOSAR computer program (Nabholz and Mayo-Bean, 2009) of EPISuite; the results of which are consistent with the measured test data. Validity and applicability of the QSAR are described in a document attached as background material to the QSAR endpoint study record.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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