Registration Dossier
Registration Dossier
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EC number: 402-860-6 | CAS number: 110553-27-0 CG 25-1320; IRGANOX 1520; TK 12229/1
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Additional information
It is well known from the literature that highly lipid - soluble chemicals given orally are initially distributed by the lymphatic system following gastric absorption yielding a slow diffusion across the membranes. The rate of entry into tissues is limited by the physico-chemical properties of the molecules.
The substance is a yellow liquid with the following physico-chemical characteristics:
- it is practically water insoluble
- it is lipophilic
- log Pow >>6
The 3-month toxicity study in rats and dogs revealed the liver as possible target organ in the high dose animals (100 and 1000 mg/kg bw in rats and 1000 mg/kg bw in dogs). The slight to moderate biliary cell proliferation may indicate the need for increased bile production and elimination via the bile. Biliary cell proliferation in general reverses slowly, so its occurrence at the end of the recovery period is not indicative of bioaccumulation or enterohepatic circulation. The substance contains functional groups that are known to undergo xenobiotic metabolism. Overall, no bioaccumulation hazard is expected.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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