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EC number: 266-582-5
CAS number: 67124-09-8
This substance is not irritating to skin or eyes.
irritation (comparable to OECD TG 404)
a key study this substance was applied to an abraded and an intact site
on each white rabbits under semi-occlusive dressing for 24 hours
(Costello, 1982). Six animals were tested in the study. Evaluation was
made on the arithmetic mean of all animals. The primary irritation was
determined to be 0.84. According to the conclusion of the study, the
substance is not irritating to skin.
irritation (similar to OECD TG 405)
a key study, 0.1 mL test substance was instilled into the conjunctival
sac of white rabbits (Costello, 1982). The test material was not washed
from the eyes.The
eyes were examined and graded for ocular reaction at 1h, and 1, 2, 3, 4,
7 days following instillation of test material into the eyes. The
overall primary ocular irritation index was 0.7 and the test substance
was unlikely to be an ocular irritant in the test animals.
6 animals were tested, the evaluation of test results was performed
according to the Example 3b (section 220.127.116.11.4. in the ECHA "Guidance on
the Application of the CLP Criteria", 2009). According to this approach
the average score is determined per animal. In this case, if 4 of 6
animals reached a cut-off value of 2.3 or above at 24, 48 and 72 hours
after patch removal, the classification as Skin Irritant is assigned.
The highest mean value for erythema/eschar and for oedema was 1.0 in
animal No.3. The mean values for other animals were all lower than 1.0.
Therefore, this substance
does not meet the requirement under EU CLP (Regulation (EC) No.
1272/2008) for classification as a skin irritant.
case of 6 rabbits, classification as eye irritant triggers if at least 4
ot 6 rabbits show a mean score of ≥
1 for the cornea and/or for iris and ≥
2 for conjunctival erythema and/or conjunctival swelling. In the eye
irritation study, the mean score of 0.0 was for cornea and for iris in
all animals grading at 24, 48 and 72 hours after instillation. The mean
score of 0.33 was for conjunctival erythema and for conjunctival
swelling only in one animal. Thefore, the substance does not meet
classification criteria under EU CLP (Regulation (EC) No. 1272/2008) as
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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