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EC number: 266-582-5 | CAS number: 67124-09-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1990-11-09 - 1991-02-22
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Comparable to guideline study; well documented study report
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 991
- Report date:
- 1991
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 434 (Acute Dermal Toxicity - Fixed Dose Procedure)
- Deviations:
- yes
- Remarks:
- At time of application of substance, the skin of 1/2 the animals t was to be abraded. This was inadvertently not done. All animals on the study had intact skin when dosed. Deviation has not compromise the study.
- GLP compliance:
- yes
- Test type:
- other: limited
- Limit test:
- yes
Test material
- Reference substance name:
- 1-(tert-dodecylthio)propan-2-ol
- EC Number:
- 266-582-5
- EC Name:
- 1-(tert-dodecylthio)propan-2-ol
- Cas Number:
- 67124-09-8
- IUPAC Name:
- 1-[(2,2-dimethyldecyl)sulfanyl]propan-2-ol
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- -Source: Charles River Wiga. Sulzfeld, West-Germany
-Age at study initiation: approx. 7 weeks
-Weight at study initiation: males: 253~276 g; females: 167~192 g.
-Fasting period before study: Feed was withheld overnight prior to dosing until approximately 3-4 h after administration of the test article.
-Housing: housed in groups of 5 per sex in polycarbonate cages containing purified sawdust as bedding material.
-Diet: free access to standard pelleted laboratory animal diet (RMH-B from Hope Farms, The Netherlannds)
-Water: free access to tap-water.
-Acclimation period: at least 5 days under laboratory conditions.
ENVIRONMENTAL CONDITIONS
-Temperature (°C): 21± 3 oC
-Humidity (%): 30-70%
-Air changes: 7.5 – 15 air changes per hr
-Photoperiod (12 hrs dark /12 hrs light)
IN-LIFE DATES: From: Jan 5th 1989 To: Jan 19th 1989
Administration / exposure
- Type of coverage:
- semiocclusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Type of wrap if used: the test material was applied to sleeves of rubber dental dam. Each sleeve will be wrapped around the trunk of the respective animal and secured with staples. An outer layer of gauze was warpped aound the trunck of each animal and secured with tape. Each rabbit was then be fitted with an appropriate restraining device to prevent the removal of the wrapping.
REMOVAL OF TEST SUBSTANCE
- Washing (if done): any unabsorbed test material remaining on the skin was removed by gentle sponging using a tower moistened with water of other solvent.
- Time after start of exposure: 24 h
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 2000 mg/kg (2.05 mL/kg)
- Constant volume or concentration used: no
VEHICLE
- Amount(s) applied (volume or weight with unit): not applicable
- Concentration (if solution): not applicable
- Lot/batch no. (if required): not applicable - Duration of exposure:
- 24 hours
- Doses:
- 2000 mg/kg body weight
- No. of animals per sex per dose:
- 5 male, 5 female
- Control animals:
- not required
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Observations at peveryday of dosing (day 1) and twice daily thereafter for at least 14 days; Bodyweight measurements taken on days 1 and 14.
- Necropsy of survivors performed: yes
- Other examinations performed: body weight, clinical signs, skin irritation, skin fur, eyes and mucous membrane, and behavior pattern, tremors, convulsion, salivations, diarrhea, lethargy, sleep and coma.
Results and discussion
- Preliminary study:
- not applicable
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- Male: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 0
Female: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 0 - Clinical signs:
- Irritation of skin was noted in all test animals. There were no other clinical signs of toxicity or behavioral changes over the 15 day observation period.
- Body weight:
- All animals showed expected bodyweight gain during the study.
- Gross pathology:
- Effects on organs:
No treatment-related macroscopic findings were observed. - Other findings:
- - Other observations: The treated skin surface of animals showed irritation.
Any other information on results incl. tables
No deaths were noted during the observation period;
Irritative effects were seen
No clinical changes were observed
All tested animals gained weight and the body weight data is shown below:
Sex |
Day 0 |
Day 15 |
Male |
2993 |
3230 |
Female |
2906 |
3207 |
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The acute dermal median lethal dose (LD50) of the test material was found to be greater than 2000 mg/kg bodyweight.
- Executive summary:
In an acute dermal toxicity study, a group of New Zealand rabbits (five male and five female) were dermally exposed to the test substance for 24 hours at a dose level of 2000 mg/kg bw. Animals then were observed for 14 days.
The treated skin surface of animals showed irritation after test material removal, but there were no other clinical signs of toxicity or behavioral changes over the 15 day observation period. Macroscopic examination of all animals at the end of the study did not reveal any changes that were considered to have arisen as a result of treatment.
The dermal LD50 was estimated to exceed 2000 mg/kg bw.
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