Phenol, isopropylated, phosphate (3:1)

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

key study

Study period:

1975, not specified

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Non GLP, not carried out according to recognised guideline, although results documented.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1976

Report date:

1976

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

other: as outlined i n 16 CFR 1500.3

Deviations:

not specified

Principles of method if other than guideline:

Test substance was administered by inhalation as supplied by the sponsor and aerosolised to 5 male and 5 female rats. Ten adult albino rats (wistar-derived strain ) equally distributed into five males and five females weighing between 200-300g were exposed to the test material administered as a volume of gas or vapor for one hour in an all glass (72 liter) chamber under the following conditions :

Air Flow: 10 liters per minute
Weight of material aerosolized: 2 g/minute
Nominal concentration of test material: 200 mg per Liter

GLP compliance:

no

Test type:

standard acute method

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

Phenol, isopropylated, phosphate (3:1)

EC Number:

273-066-3

EC Name:

Phenol, isopropylated, phosphate (3:1)

Cas Number:

68937-41-7

Molecular formula:

CXHYO4P X and Y are variable dependant on the molecular component.

IUPAC Name:

Phenol, isopropylated, phosphate (3:1)

Details on test material:

Specified only as Product No . X-50; Kronitex 50 ; Lot 5-101.
No other information on the test material is provided within the report.

Test animals

Species:

rat

Strain:

Wistar

Sex:

male/female

Details on test animals or test system and environmental conditions:

The test utilised ten adult albino rats (wistar-derived strain ) equally distributed into five males and five females weighing between 200-300g. No other information is detailed.

Administration / exposure

Route of administration:

inhalation: aerosol

Type of inhalation exposure:

whole body

Vehicle:

air

Details on inhalation exposure:

Ten adult albino rats (wistar-derived strain ) equally distributed into five males and five females weighing between 200-300g were exposed to the test material administered as a volume of gas or vapor for one hour in an all glass (72 liter) chamber under the following conditions :
Air Flow: 10 liters per minute
Weight of material aerosolized: 2 g/minute
Nominal concentration of test material: 200 mg per Liter

Analytical verification of test atmosphere concentrations:

no

Duration of exposure:

1 h

Concentrations:

200 mg/l

No. of animals per sex per dose:

5 animals per sex per dose

Control animals:

no

Details on study design:

Ten adult albino rats (wistar-derived strain ) equally distributed into five males and five females weighing between 200-300g were exposed to the test material administered as a volume of gas or vapor for one hour in an all glass (72 liter) chamber under the following conditions :
Air Flow: 10 liters per minute
Weight of material aerosolized: 2 g/minute
Nominal concentration of test material: 200 mg per Liter

Statistics:

None

Results and discussion

Preliminary study:

Not applicable.

Effect levels

Sex:

male/female

Dose descriptor:

LC50

Effect level:

> 200 mg/L air

Based on:

test mat.

Exp. duration:

1 h

Mortality:

1 death on Day 7.

Clinical signs:

other: No data.

Body weight:

No data.

Gross pathology:

No findings.

Other findings:

No acute symptoms were observed prior: to death. Gross examination at autopsy of the one animal that died revealed no noteworthy findings.

Any other information on results incl. tables

Mortality data

Dose level mg/l	No. rats dosed	deaths per day														Mortality after 14 days
		1	2	3	4	5	6	7	8	9	10	11	12	13	14
200	5M	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0/5

 

200

5F

0

0

0

0

0

0

1

0

0

0

0

0

0

0

1/5

Applicant's summary and conclusion

Interpretation of results:

not classified

Remarks:

Migrated information Criteria used for interpretation of results: EU

Conclusions:

The substance demonstrated a 10% mortality rate and has been completed as a limit test at 200 mg/l The LD50 is considered to be >200 mg/l.

Executive summary:

The test sample was dosed by inhalation to 5 male and 5 female rats at a dose of 200 mg/l. Assessed over a 14 day period, 0 male and 1 female deaths occurred and the study was completed as a limit test. The LC50 is considered >200 mg/l.

 

No classification is applicable based on the results.