Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 476-700-9 | CAS number: 15365-14-7
Toxicological Summary
Administrative data
Workers - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 4.2 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 12.5
- Dose descriptor starting point:
- NOAEL
- Value:
- 30 mg/kg bw/day
- Modified dose descriptor starting point:
- NOAEC
- Value:
- 52.9 mg/m³
- Explanation for the modification of the dose descriptor starting point:
The critical Point of Departure used to derive the DNEL is the NOAEL for maternal toxicity of 30 mg/kg bw/day
Oralidentified in the prenatal developmental toxicity study in rats exposed orally. Modification of the starting dose descriptor
was performed according to ECHA guidance
identified in the prenatal developmental toxicity study in rats exposed orally.
- AF for dose response relationship:
- 1
- Justification:
- ECHA-Default according to R8 ECHA 2010
- AF for differences in duration of exposure:
- 1
- Justification:
- ECHA-Default according to R8 ECHA 2010
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- A factor of 4 is included in the determination of NOAEC(human) accordimg to Reach guidance R8.2
- AF for other interspecies differences:
- 2.5
- Justification:
- ECHA-Default according to R8 ECHA 2010
- AF for intraspecies differences:
- 5
- Justification:
- ECHA-Default according to R8 ECHA 2010
- AF for the quality of the whole database:
- 1
- AF for remaining uncertainties:
- 1
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Workers - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 1 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Dermal
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 100
- Dose descriptor starting point:
- NOAEL
- Value:
- 100 mg/kg bw/day
- Explanation for the modification of the dose descriptor starting point:
- A dermal subchronic study is available
- AF for dose response relationship:
- 1
- Justification:
- ECHA-Default according to R8 ECHA 2010
- AF for differences in duration of exposure:
- 2
- Justification:
- ECHA-Default according to R8 ECHA 2010
- AF for interspecies differences (allometric scaling):
- 4
- Justification:
- ECHA-Default according to R8 ECHA 2010
- AF for other interspecies differences:
- 2.5
- Justification:
- ECHA-Default according to R8 ECHA 2010
- AF for intraspecies differences:
- 5
- Justification:
- ECHA-Default according to R8 ECHA 2010
- AF for the quality of the whole database:
- 1
- Justification:
- ECHA-Default according to R8 ECHA 2010
- AF for remaining uncertainties:
- 1
- Justification:
- ECHA-Default according to R8 ECHA 2010
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
Workers - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- no hazard identified
Additional information - workers
General Population - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
General Population - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
General Population - Hazard via oral route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
General Population - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- no hazard identified
Additional information - General Population
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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