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Environmental fate & pathways

Biodegradation in water: screening tests

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Description of key information

Key information is contributed by a study of Cognis, Borowivcz 1998 (GLP), which was conducted with the read-across substance 577-11-7 (Docusate Sodium). Justification for read-across: CAS 2373-38-8 belongs to the same category as CAS 577 -11 -7, which is the worst case representative of this category. Hence biodegradation results of CAS 577 -11 -7 are appropriate to characterize the biodegradation of CAS 2373-38-8. The justification for read-across and the category definition is provided in Chapter 13. The read-across study was conducted using analytical grade Docusate Sodium (98% pure). Furthermore, it applied test guideline ISO 14593, i.e., the reference method of 648/2004/EEC. ISO 14593 which is equivalent to OECD 310. The results of the study indicate that more than 90% of the test substance was degraded within 28 days, respectively. The results of the study indicate that Docusate Sodium is readily biodegradable. Based on the read-across justification in Chapter 13, it is concluded that CAS 2373-38-8 is readily biodegradable.
The results of the corresponding, valid key study which is appropriate for the assessment of ready biodegradability of surfactants according to 648/2004/EEC clearly show that the substance is readily biodegradable. Based on this finding, further exposure and risk assessment for environmental compartments like surface water bodies, sediments and soils is obsolete, according to the requirements of REACH.

Key value for chemical safety assessment

Biodegradation in water:
readily biodegradable

Additional information

Two existing studies reported 1988 and 1991 were scored Klimisch 3 (not reliable) and hence the results were will not be used for the hazard assessment of CAS 2373 -38 -8.