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Toxicological information

Neurotoxicity

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Description of key information

Key value for chemical safety assessment

Additional information

No effects on neurotoxicity (functional observational battery and motor activity) were observed in a repeated dose/one generation reproduction study (OECD 422), nor were any clinical signs suggestive of neurotoxicity observed in any other studies following acute exposure by oral, dermal, or inhalation routes of exposure.

Justification for classification or non-classification

Based on the lack of adverse effects on neurotoxicity at the highest dose tested (1000 mg/kg/day) in a repeated-dose toxicity study and the lack of evidence of neurotoxicity in acute toxicity studies, the test substance does not need to be classified for neurotoxicity or specific toxicity according to EU Directive 67/548/EEC and EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008.