Registration Dossier
Registration Dossier
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EC number: 205-440-9 | CAS number: 140-90-9
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Single dose
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Justification for type of information:
- Old test report, but sufficient to conclude classification
Note that the large numbers of animals over an excessive number of dose levels was normal for that period in the US
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 951
- Reference Type:
- publication
- Title:
- Sodium ethyl xanthate. Priority existing chemical no. 5. NICNAS
- Author:
- Australian Government Publishing Service
- Year:
- 1 995
- Bibliographic source:
- Australian Government Publishing Service
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- not specified
- GLP compliance:
- not specified
- Remarks:
- This study predates the requirements for good laboratory practice, however the study was considered adequate for this assessment
Test material
- Reference substance name:
- Sodium O-ethyl dithiocarbonate
- EC Number:
- 205-440-9
- EC Name:
- Sodium O-ethyl dithiocarbonate
- Cas Number:
- 140-90-9
- Molecular formula:
- C3H6OS2.Na
- IUPAC Name:
- sodium (ethoxymethanethioyl)sulfanide
- Test material form:
- other: 10% water solution of sodium ethyl xanthate (CAS# 140-90-9)
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- other: albino
- Sex:
- male
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- not specified
- Doses:
- 500 - 5000 mg/kg single dose
- No. of animals per sex per dose:
- Up to 13 animals per dose group
- Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 730 mg/kg bw
- Mortality:
- Yes. At dose levels of 750 mg/kg and above
- Clinical signs:
- other: The target organs for oral toxicity were the central nervous system, liver and spleen. The majority of death occurred on the first day, and the animals that survived appeared normal within two days
- Gross pathology:
- Depression followed by hyperexcitability, tremors, paralysis exophtaalmia and clonic followed by tonic convulsions.
Pinkness of feet and nose, preening and salivation. Consolidated lungs, pale granular livers, unusually small spleens and atonic intestine. Surviving animals showed no abnormalities
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- Considered valid for classification is within expected values for the class of substance.
Other studies lead to same classification conclusions.
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