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EC number: 205-517-7
CAS number: 141-98-0
Stimulation indices (SI):
Group 1, negative control
Group 3, 10%
Group 4, 25%
Lymph node cell count
Lymph node weight
different from control at p ≤ 0.01
Treatment with IPETC
concentrations of 5%, 10% or 25% did not reveal statistical
significantly increased values for lymph node cell
count. The stimulation indices of the lymph node cell count did not
exceed the threshold level of 1.4. Hence, the test item is classified as
not sensitising. No effect was observed in the lymph node weight, either.
The threshold level for the ear weight
of 1.1 was not exceeded and no increase of ear thickness was observed,
i.e. no irritating properties were noted.
The positive control group caused the expected increases in lymph
node cell countand lymph node
weight(statistically significant atp ≤ 0.01).Therefore,
the study can be regarded as valid.
No signs of local or systemic
intolerance were recorded. The animal body weight of the high dose group
is reduced compared to all other groups.
In conclusion, under the present test conditions, IPETC at
concentrations of 5%, 10% or 25% (w/w)inacetone/olive
oil (3+1, v/v)did
not reveal any sensitising properties in the local lymph node assay.
The substance has been shown not to exibit skin sensitising properties
requiring classification as a skin senzitiser according to Regulation
(EC) 1272/2008, and is therefore not classified as such.
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