Registration Dossier

Administrative data

Endpoint:
hydrolysis
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2016
Report Date:
2016

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
OECD Guideline 111 (Hydrolysis as a Function of pH)
GLP compliance:
no
Remarks:
GLP study not necessary here

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
The test material used in this study was a clear, brown liquid. It was supplied by Chevron Chemical Company, Oronite Technical Division, San Francisco, California.

Study design

Analytical monitoring:
yes
Details on test conditions:
Testing temperature 50°C.

Purge liquid with nitrogen to remove air.

Testing period 5 days
Duration of testopen allclose all
Duration:
5 d
pH:
4
Temp.:
50 °C
Initial conc. measured:
11.9 ca. other: PPM
Duration:
5 d
pH:
7
Temp.:
50 °C
Initial conc. measured:
ca. 12.8 ca. other: PPM
Duration:
5 d
pH:
9
Temp.:
50 °C
Initial conc. measured:
ca. 13.5 other: PPM

Results and discussion

Preliminary study:
The preliminary test for hydrolysis as a function of pH (OECD 111) is subjecting the buffer solutions to 50C for 5 days. If the change in concentration is <10% the test article is considered hydrolytically stable (t0.525C > 1year). Based on the data in this study, CAS 220795-20-0 is hydrolytically stable at pH 4, 7 and 9 and no further testing is required.
Transformation products:
no
Total recovery of test substance (in %)open allclose all
% Recovery:
ca. -2.1
pH:
4
Temp.:
50 °C
Duration:
ca. 5 d
% Recovery:
ca. -0.5
pH:
7
Temp.:
50 °C
Duration:
ca. 5 d
% Recovery:
ca. -1.1
pH:
9
Temp.:
50 °C
Duration:
ca. 5 d
Dissipation DT50 of parent compoundopen allclose all
Key result
pH:
4
Remarks on result:
hydrolytically stable based on preliminary test
Key result
pH:
7
Temp.:
50 °C
Remarks on result:
hydrolytically stable based on preliminary test
Key result
pH:
9
Temp.:
50 °C
Remarks on result:
hydrolytically stable based on preliminary test

Any other information on results incl. tables

Conclusion

 

The preliminary test for hydrolysis as a function of pH (OECD 111) is subjecting the buffer solutions to 50C for 5 days. If the change in concentration is <10% the test article is considered hydrolytically stable (t0.525C> 1year). Based on the data in this study,CAS 220795-20-0ishydrolytically stable at pH 4, 7 and 9 and no further testing is required.

Applicant's summary and conclusion

Conclusions:
Conclusion

The preliminary test for hydrolysis as a function of pH (OECD 111) is subjecting the buffer solutions to 50C for 5 days. If the change in concentration is <10% the test article is considered hydrolytically stable (t0.525C > 1year). Based on the data in this study, CAS 220795-20-0 is hydrolytically stable at pH 4, 7 and 9 and no further testing is required.