Registration Dossier
Registration Dossier
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EC number: 208-793-7 | CAS number: 541-85-5
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1949
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Well documented non-GLP study for several substances
Data source
Reference
- Reference Type:
- publication
- Title:
- Range-finding toxicity data: List III
- Author:
- Smyth H.F, Carpenter C.P, Weil C.S
- Year:
- 1 949
- Bibliographic source:
- Journal. Ind. Hyg. and Tox, Issue 1 (31): p60, 1949
Materials and methods
- Principles of method if other than guideline:
- Penetration of rabbit skin estimated by a cuff method using groups of four male rats, exposing the skin to hexan-2-one for 24 hours.
- GLP compliance:
- no
- Remarks:
- study performed before the introduction of GLP
- Limit test:
- no
Test material
- Reference substance name:
- 3-heptanone
- IUPAC Name:
- 3-heptanone
- Reference substance name:
- Heptan-3-one
- EC Number:
- 203-388-1
- EC Name:
- Heptan-3-one
- Cas Number:
- 106-35-4
- Molecular formula:
- C7H14O
- IUPAC Name:
- heptan-3-one
Constituent 1
Constituent 2
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- New Zealand giant albino rabbit.
Administration / exposure
- Type of coverage:
- occlusive
- Details on dermal exposure:
- The dose was retained beneath an impermeable plastic film in contact with the body surface
- Duration of exposure:
- 24 hours
- Doses:
- up to 20 ml/kg bw
- No. of animals per sex per dose:
- 6
- Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- approximate LD50
- Effect level:
- > 20 mL/kg bw
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information according to EU GHS or dangerous substance directive Criteria used for interpretation of results: EU
- Conclusions:
- 3-heptanone is not toxic via an dermal exposure according to the EU classification system
- Executive summary:
Acute dermal toxicity to rabbits of 3-heptanone was investigated in a single-dose dermal toxicity study. Dosing was performed by exposing the body surface with 3-heptanone retained on the skin with an impermeable plastic film and mortality was observed for 14 days after dosage. Groups of 5 male animals were used per dose. The LD50 for 3-heptanone was above 20 ml/kg bw, corresponding to 16400 mg/kg bw which is above the classification threshold for acute oral toxicity of 2000 mg/kg bw according to Regulation (EC) 1272/2008 or Directive 67/548/EEC.
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