1,3-dihydro-5-methoxy-2H-benzimidazole-2-thione

Particle size distribution (Granulometry)

Link to relevant study record(s)

Reference

Endpoint:

particle size distribution (granulometry)

Type of information:

experimental study

Adequacy of study:

key study

Study period:

22/2/2016 - 22/2/2016

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

test procedure in accordance with national standard methods

Justification for type of information:

Experimental result using standard methods of analysis

Qualifier:

according to guideline

Guideline:

other: as mention below

Principles of method if other than guideline:

The particle size distribution of test item was determined by granulometric analysis with rotap sieve shaker

GLP compliance:

no

Type of method:

sieving

Type of particle tested:

primary particle

Type of distribution:

counted distribution

Specific details on test material used for the study:

- Name of test material : 5-methoxy-1,3-dihydro-2H-benzimidazole-2-thione
- Molecular formula : C8H8N2OS
- Molecular weight : 180.2302 g/mol
- Smiles notation : COc1ccc2c(c1)nc([nH]2)S
- InChl : 1S/C8H8N2OS/c1-11-5-2-3-6-7(4-5)10-8(12)9-6/h2-4H,1H3,(H2,9,10,12)
- Substance type : Organic
- Physical state : Solid

Key result

Percentile:

D50

Remarks on result:

other: Mass median diameter

No.:

#1

Size:

150 µm

Distribution:

94.37 %

Remarks on result:

other: No other detail available

No.:

#2

Size:

106 µm

Distribution:

3.04 %

Remarks on result:

other: No other detail available

No.:

#3

Size:

75 µm

Distribution:

1.24 %

Remarks on result:

other: No other detail available

OBSERVATION TABLE:

Amount of test item weighed (g) =10.034 g

Method run time (minutes) =10 min

Weight of butter paper (g) = 0.198 g

Sieve sizes(in microns)	Weight of butter paper + test item (g)	Test item quantity retained after sieving (g)	Percentage (%) of test item*
150 microns	9.437 g	9.437 g	94.37%
106 microns	0.304 g	0.304 g	3.04%
75 microns	0.322 g	0.124 g	1.24%
53 microns	---	----	-----
25 microns	---	----	-----
10 microns	---	----	-----

Conclusions:

The particle size distribution of test item was determined by granulometric analysis with rotap sieve shaker. The particle size distribution was determine to be in the range of 150 micron to 75 micron.

Executive summary:

The particle size distribution of test item was determined by granulometric analysis with rotap sieve shaker. The particle size distribution was determine to be in the range of 150 micron to 75 micron.

Description of key information

The particle size distribution of test item was determined by granulometric analysis with rotap sieve shaker. The particle size distribution was determine to be in the range of 150 micron to 75 micron.

Additional information

The particle size distribution of test item was determined by granulometric analysis with rotap sieve shaker. The particle size distribution was determine to be in the range of 150 micron to 75 micron.