Sodium 2-(2-dodecyloxyethoxy)ethyl sulphate

Acute Toxicity: dermal

Administrative data

Endpoint:

acute toxicity: dermal

Type of information:

migrated information: read-across based on grouping of substances (category approach)

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Data source

Reference

Reference Type:

publication

Title:

DERMAL TOXICITY OF SODIUM LAURYL SULFATE

Author:

STEVEN CARSO, BERNARD L. OSER

Year:

1964

Bibliographic source:

J. soc. cos. CHEM. 15, 137-147 (1964)

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

other:

Principles of method if other than guideline:

Acute dermal toxicity of Sodium lauryl sulphate was assessed in Rabbits.

GLP compliance:

not specified

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Sodium dodecyl sulphate

EC Number:

205-788-1

EC Name:

Sodium dodecyl sulphate

Cas Number:

151-21-3

Molecular formula:

C12H25NaO4S

IUPAC Name:

sodium dodecyl sulfate

Details on test material:

- Name of test material : Sodium Dosecyl Sulphate
- Molecular formula : NaC12H25SO4
- Molecular weight : 288.372
- Substance type : Organic
- Physical state : Solid

Test animals

Species:

rabbit

Strain:

not specified

Sex:

male

Administration / exposure

Type of coverage:

other: Intact and abraded skin

Vehicle:

water

Details on dermal exposure:

Sodium lauryl sulfate (SLS) was dissolved in water to make slurry

Duration of exposure:

24 hrs

Doses:

150, 300, 600, 1200, 2000 mg/kg bw

No. of animals per sex per dose:

10 males

Control animals:

not specified

Details on study design:

- Duration of observation period following administration : two-weeks period
- Other examinations performed : Gross pathological changes were noted. Mean primary irritation score, body weight changes and appearance of the skin at the site of application after 14 days was also noted.

Results and discussion

Effect levels

Sex:

male

Dose descriptor:

LD50

Effect level:

580 mg/kg bw

Based on:

test mat.

Mortality:

Mortality was observed

Clinical signs:

other: Slight scaling and wrinkling of skin was also observed

Gross pathology:

Tremors, tonic-clonic convulsions and respiratory failure were characteristically seen

Other findings:

Primary irritation score obtained after 24 to 72 hrs of application varies from 3 to 4.2

Applicant's summary and conclusion

Interpretation of results:

Toxicity Category IV

Remarks:

Migrated information Criteria used for interpretation of results: EU

Conclusions:

The Acute dermal LD50 value of Sodium Lauryl sulphate in rabbit was observed at dose concentration of 580 + 138 mg/kg body weight

Executive summary:

The purpose of this study was to evaluate the dermal toxicity of Sodium lauryl sulphate, 33% slurry of Sodium lauryl sulphate in water was administered on tointact and abraded skin of rabbit at dose concentration of 150, 300, 600, 1200, 2000 mg/kg bw for 24 hrs and observed for 2 weeks,the mean maximum primary skin irritation score and their body weights were recorded. All that died and the survivors at 14 days were necropsied and gross pathological changes were noted.

Mortalities were observed between 20 to 40 %. Slight scaling and wrinkling of skin was observed.Tremors, tonic-clonic convulsions and respiratory failure were characteristically seen.Primary irritation score obtained after 24 to 72 hrs of application varies from 3 to 4 with the LD50 value of580+138 mg/kg body weight.