Registration Dossier

Administrative data

Description of key information

No required at the registration tonnage band

Key value for chemical safety assessment

Repeated dose toxicity: via oral route - systemic effects

Endpoint conclusion
Endpoint conclusion:
no study available

Repeated dose toxicity: inhalation - systemic effects

Endpoint conclusion
Endpoint conclusion:
no study available (further information necessary)

Repeated dose toxicity: inhalation - local effects

Endpoint conclusion
Endpoint conclusion:
no study available

Repeated dose toxicity: dermal - systemic effects

Endpoint conclusion
Endpoint conclusion:
no study available

Repeated dose toxicity: dermal - local effects

Endpoint conclusion
Endpoint conclusion:
no study available

Additional information

The substance under registration (CAS 28950-61-0) belongs to the category of Stilbene Fluorescent Whitening Agents. All members of this category are organic salts with high molecular weight, solids with high thermal stability, low Kow and high to very high water solubility.

They do not show acute toxic effects after oral, inhalation, and dermal administration. They are neither irritant to skin nor eyes, nor genotoxic in-vitro and in-vivo, nor sensitizing. Six over fourteen registered substances were tested for subchronic toxicity and four of them were tested for chronic toxicity up to two years with no relevant toxic effects.

They are mainly excreted in the faeces in a few hours by oral administration and practically not absorbed by skin, therefore no systemic effects are expected.


Justification for selection of repeated dose toxicity via oral route - systemic effects endpoint:
Not required according to REACH Annex VII

Justification for selection of repeated dose toxicity inhalation - systemic effects endpoint:
Not required according to REACH Annex VII

Justification for selection of repeated dose toxicity inhalation - local effects endpoint:
No required at the registration tonnage band

Justification for selection of repeated dose toxicity dermal - systemic effects endpoint:
No required at the registration tonnage band

Justification for selection of repeated dose toxicity dermal - local effects endpoint:
No required at the registration tonnage band

Justification for classification or non-classification