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Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data is from peer-reviewed journal

Data source

Reference
Reference Type:
publication
Title:
A toxicologic and dermatologic assessment of cinnamyl alcohol, cinnamaldehyde and cinnamic acid when used as fragrance ingredients
Author:
D. Bickers, P. Calow, H. Greim, J.M. Hanifin, A.E. Rogers, J.H. Saurat, I.G. Sipes, R.L. Smith, H. Tagami
Year:
2005
Bibliographic source:
Food and Chemical Toxicology 43 (2005) 799–836

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: as mentioned below
Principles of method if other than guideline:
The study was conducted to evaluate the acute eye irritation potential of the test chemical in rabbits.
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
solid: crystalline
Details on test material:
Name of the test chemical: Cinnamic Acid
Molecular Formula: C9H8O2
Molecular Weight: 148.1602 g/mol
Substance Type: Organic
Physical State: Solid
InChI: 1S/C9H8O2/c10-9(11)7-6-8-4-2-1-3-5-8/h1-7H,(H,10,11)

Test animals / tissue source

Species:
rabbit
Strain:
not specified
Details on test animals or tissues and environmental conditions:
no data

Test system

Vehicle:
water
Remarks:
(Distilled water)
Controls:
not specified
Amount / concentration applied:
TEST MATERIAL
- Concentration: 10mg/ml (1%)
0.1-1%
VEHICLE
- Amount(s) applied (volume or weight with unit): No data available
- Concentration (if solution): No data available
- Lot/batch no. (if required): No data available
- Purity: No data available
Duration of treatment / exposure:
No data available
Observation period (in vivo):
No data available
Number of animals or in vitro replicates:
No data available
Details on study design:
No data available

Results and discussion

In vivo

Results
Irritation parameter:
other: Investigation of eye irritancy effects
Basis:
mean
Time point:
other: no data available
Reversibility:
not specified
Remarks on result:
no indication of irritation
Irritant / corrosive response data:
The test chemical at dose levels up to 10mg/ml (1%) was non-irritating to rabbit eyes.

Applicant's summary and conclusion

Interpretation of results:
other: not irritating
Conclusions:
The test chemical at dose levels up to 10mg/ml (1%) was non-irritating to rabbit eyes. Hence, it can be considered to be not irritating to eyes.
Executive summary:

The study was conducted to evaluate the acute eye irritation potential of the test chemical in rabbit. 0.1 -1% test chemical in distilled water was instilled into the eyes of rabbits and observed for effects [duration of exposure, observation period not specified]. The test chemical at dose levels up to 10mg/ml (1%) was non-irritating to rabbit eyes. Hence, it can be considered to be not irritating to eyes.