Cinnamyl alcohol

Endpoint summary

Description of key information

Short-term toxicity to fish:

Study was conducted to assess the effect of test chemical on the mortality of fish Danio rerio. Test conducted according to OECD Guideline 203 (Fish, Acute Toxicity Test).The test substance was soluble in water. Therefore, the test solution was prepared by dissolving 70 mg, 80 mg and 90mg of the test substance in 10 liters deionized water with continuous stirring for achieving test concentrations of 7 mg/L, 8 mg/L and 9mg/L, respectivelyand Zebra FishDanio reriowere exposed to these concentration for 96 hours.Bowl aquaria containing 2 liters of potable water (passed through reverse osmosis system) were loaded with 8 fishes. A static procedure was used for the study and it was conducted in compliance with the OECD guideline 203.The nominal concentarion were used7 , 8 , 9 , 11 , 12.5 , 25 , 50, 100 mg/l .After 96 hours of exposure to test item to various nominal test concentrations, LC50 was determine to be 9 mg/l . Based on the LC50, it can be consider that the chemical was toxic and can be consider to be classified as aquatic chronic 2 as per the CLP classification criteria.

Short-term toxicity to aquatic invertebrates:

Aim of this study was to assess the short term toxicity of test material to aquatic invertebrates daphnia magna. Study was performed according to the OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test) in a static system for the total exposure period of 48 hrs.

 Short term toxicity of test chemical to aquatic invertebrates was performed according to the OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test) in a static system.0.3 , 0.6 , 1.2 , 2.5 , 5.0 , 10.0 mg/lconcentrations were used in the study. Effects on immobilisation were observed for 48 hours. With the test substance one positive control Potassium dichromate (K2Cr2O7) was also run simultaneously. After the exposure of chemical, effect concentration EC50 was calculated using nonlinear regression by the software Prism 4.0.

 The median effective concentration (EC50) for the test substance, in Daphnia magna was determined to be 7.7 mg/L on the basis of mobility inhibition effects in a 48 hour study. Based on the EC50 value, substance is likely to be hazardous to aquatic invertebrate and can be classified as aquatic chronic 2 category as per the CLP classification criteria.

Toxicity to aquatic algae and cyanobacteria:

Aim of this study was to evaluate the nature of chemical test chemical when comes in contact with the test organism Desmodesmus subspicatus (previous name: Scenedesmus subspicatus). Test was conducted according to the OECD guideline 201.The stock solution 100.0 mg/l was prepared by dissolving colourless dense liquid in OECD growth medium. Test solutions of required concentrations were prepared by mixing the stock solution of the test sample with OECD growth medium and inoculum culture.0.5 , 1.0 , 2.0 , 4.0 , 8.0 , 16.0 , 32.0 mg/lVarious concentration were used.

With the test substance one positive control Potassium dichromate (K2Cr2O7) was also run simultaneously. After the exposure of chemical, effect concentration EC50 was calculated using nonlinear regression by the software Prism 4.0. Effect on the growth of algae was determine after an exposure period of 72 hrs.

The median effective concentration (EC50) for the test substance , in algae was determined to be 19.7 mg/L on the basis of growth rate inhibition effects in a 72 hour study. Based on the EC50 value, which indicates that the substance is likely to be hazardous to aquatic algae can be classified as aquatic chronic 3 category as per the CLP classification criteria.

Toxicity to microorganisms:

A test was developed using Tetrahymena pyriformis in order to determine the toxicity of test material. The concentration of the chemi cal, at which the inhibition of test organism i.e T. pyriformis was observed (IC50), was determined. The Inhibition concentration (IC50) of test material in tetrahymena pyriformis was observed to be 161.27 mg/L on the basis of population growth rate effect in a 48.0 hours of exposure.

Additional information

Short-term toxicity to fish:

Study was conducted to assess the effect of test chemical on the mortality of fish Danio rerio. Test conducted according to OECD Guideline 203 (Fish, Acute Toxicity Test).The test substance was soluble in water. Therefore, the test solution was prepared by dissolving 70 mg, 80 mg and 90mg of the test substance in 10 liters deionized water with continuous stirring for achieving test concentrations of 7 mg/L, 8 mg/L and 9mg/L, respectivelyand Zebra FishDanio reriowere exposed to these concentration for 96 hours.Bowl aquaria containing 2 liters of potable water (passed through reverse osmosis system) were loaded with 8 fishes. A static procedure was used for the study and it was conducted in compliance with the OECD guideline 203.The nominal concentarion were used7 , 8 , 9 , 11 , 12.5 , 25 , 50, 100 mg/l .After 96 hours of exposure to test item to various nominal test concentrations, LC50 was determine to be 9 mg/l . Based on the LC50, it can be consider that the chemical was toxic and can be consider to be classified as aquatic chronic 2 as per the CLP classification criteria.

Short-term toxicity to aquatic invertebrates:

Aim of this study was to assess the short term toxicity of test material to aquatic invertebrates daphnia magna. Study was performed according to the OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test) in a static system for the total exposure period of 48 hrs.

 Short term toxicity of test chemical to aquatic invertebrates was performed according to the OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test) in a static system.0.3 , 0.6 , 1.2 , 2.5 , 5.0 , 10.0 mg/lconcentrations were used in the study. Effects on immobilisation were observed for 48 hours. With the test substance one positive control Potassium dichromate (K2Cr2O7) was also run simultaneously. After the exposure of chemical, effect concentration EC50 was calculated using nonlinear regression by the software Prism 4.0.

 The median effective concentration (EC50) for the test substance, in Daphnia magna was determined to be 7.7 mg/L on the basis of mobility inhibition effects in a 48 hour study. Based on the EC50 value, substance is likely to be hazardous to aquatic invertebrate and can be classified as aquatic chronic 2 category as per the CLP classification criteria.

Toxicity to aquatic algae and cyanobacteria:

Aim of this study was to evaluate the nature of chemical test chemical when comes in contact with the test organism Desmodesmus subspicatus (previous name: Scenedesmus subspicatus). Test was conducted according to the OECD guideline 201.The stock solution 100.0 mg/l was prepared by dissolving colourless dense liquid in OECD growth medium. Test solutions of required concentrations were prepared by mixing the stock solution of the test sample with OECD growth medium and inoculum culture.0.5 , 1.0 , 2.0 , 4.0 , 8.0 , 16.0 , 32.0 mg/lVarious concentration were used.

With the test substance one positive control Potassium dichromate (K2Cr2O7) was also run simultaneously. After the exposure of chemical, effect concentration EC50 was calculated using nonlinear regression by the software Prism 4.0. Effect on the growth of algae was determine after an exposure period of 72 hrs.

The median effective concentration (EC50) for the test substance , in algae was determined to be 19.7 mg/L on the basis of growth rate inhibition effects in a 72 hour study. Based on the EC50 value, which indicates that the substance is likely to be hazardous to aquatic algae can be classified as aquatic chronic 3 category as per the CLP classification criteria.

Toxicity to microorganisms:

A test was developed using Tetrahymena pyriformis in order to determine the toxicity of test material. The concentration of the chemi cal, at which the inhibition of test organism i.e T. pyriformis was observed (IC50), was determined. The Inhibition concentration (IC50) of test material in tetrahymena pyriformis was observed to be 161.27 mg/L on the basis of population growth rate effect in a 48.0 hours of exposure.