Registration Dossier
Registration Dossier
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EC number: 246-644-8 | CAS number: 25134-21-8
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
ErC50= >100 mg/L; ErC10 = 92.6 mg/L; NOEC = 66.7 mg/L
Key value for chemical safety assessment
- EC10 or NOEC for freshwater algae:
- 92.6 mg/L
Additional information
Algal growth inhibitionto the unicellular freshwater green alga Pseudokirchneriella subcapitata was has been investigated according to OECD/EU test methods. The substance was found to inhibit the growth after 72 hours exposure. The EC50 values for inhibition of specific growth rate (ErC50) and yield (EyC50) being >100mg/L. EC10 values for inhibition of specific growth rate (ErC50) was 92.6 mg/L and yield (EyC50) was 74.7mg/L.NOEC was determined to be 66.7 mg/L. The test substance rapidly hydrolyses in water yielding the di-acid degradation product that significantly affected pH. A limit test conducted at a concentration of 100 mg/L and with adjustment of pH had no significant effects on growth of the algae.
In accordance with ECHA guidance on information requirements and chemical safety assessment, Chapter R.7b: Endpoint specific guidance, the ErC50 endpoint is used in DNEL derivation. This is because use of values based on biomass cannot be applied to an analysis of results from a system in exponential growth without logarithmic transformation.
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