Registration Dossier
Registration Dossier
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EC number: 247-728-7 | CAS number: 26479-35-6
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Administrative data
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Additional information
Cheng et al. (2005) investigated the stability of 3 mM potassium allophonate in 10, 50, or 100 mM sodium phosphate buffer at pH 8.0, in 100 mM sodium phosphate buffer at pH 7.3, and in 7.3 mM sodium phosphate buffer at acidic pH (achieved by addition of perchloric acid) in 14-hour hydrolysis assays. Allophonate readily underwent decarboxylation to exclusively form urea at neutral and acidic pHs and in moderate to high buffer concentrations. When potassium allophonate was treated with 0.5 N perchloric acid, a half-life of seconds to minutes was determined. In 10 mM phosphate buffer at pH 8.0, a half-life of ca. 50 hours was estimated. When tested with 100 mM buffer, the estimated half life decreased significantly to ca. 17 hours. When tested with 100 mM buffer at pH 8.0, the half life was determined to be 3 hours. Providing supporting information for stability at alkaline pH, a hydrolysis study performed on potassium allophonate in a sodium phosphate buffer (pH 8.0), found that potassium allophonate was stable to hydrolysis (Ricerca Biosciences, 2013). These data show that hydrolysis of potassium allophonate to urea will proceed at environmentally-relevant pH and that the rate of transformation increases as the pH becomes more acidic.
References:
Cheng, G., Shapir, N., Sadowsky, M. J. and Wackett, L. P. 2005. Allophonate hydrolase, not urease, functions in bacterial cyanuric acid metabolism. Applied and Environmental Microbiology, 71(8): 4437 -45.
Ricerca Biosciences, LLC. 2013. Metabolic Stability of Potassium Allophonate and Formation of Urea in Rat Liver Microsomes. Testing laboratory: Ricerca Biosciences, LLC, Drug Safety and Metabolism, 7528 Auburn Road, Concord OH 44077. Report no.: 029722. Report date: 2013-03-01.
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