Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 263-214-5 | CAS number: 61792-11-8
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- No data
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Meets generally accepted scientific standards with acceptable restrictions.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 969
- Report date:
- 1969
Materials and methods
- Principles of method if other than guideline:
- Each of 3 animals had 0.1 ml of test sample instilled into the right eye. The untreated left eye served as the control. Both the treated and control eyes were examined every 24 hours for 4 days and then again on the 7th day. Scorings were made according to the Draize scale for scoring ocular lesions.
- GLP compliance:
- no
- Remarks:
- Study predates GLP
Test material
- Reference substance name:
- (2Z/6Z)-3,7-dimethylnona-2,6-dienenitrile
- Molecular formula:
- C11H17N
- IUPAC Name:
- (2Z/6Z)-3,7-dimethylnona-2,6-dienenitrile
- Reference substance name:
- (2Z/6E)-3,7-dimethylnona-2,6-dienenitrile
- Molecular formula:
- C11H17N
- IUPAC Name:
- (2Z/6E)-3,7-dimethylnona-2,6-dienenitrile
- Reference substance name:
- (2E/6Z)-3,7-dimethylnona-2,6-dienenitrile
- Molecular formula:
- C11H17N
- IUPAC Name:
- (2E/6Z)-3,7-dimethylnona-2,6-dienenitrile
- Reference substance name:
- (2E/6E)-3,7-dimethylnona-2,6-dienenitrile
- Molecular formula:
- C11H17N
- IUPAC Name:
- (2E/6E)-3,7-dimethylnona-2,6-dienenitrile
- Reference substance name:
- (3E/6Z)-3,7-dimethylnona-3,6-dienenitrile
- Molecular formula:
- C11H17N
- IUPAC Name:
- (3E/6Z)-3,7-dimethylnona-3,6-dienenitrile
- Reference substance name:
- (3E/6E)-3,7-dimethylnona-3,6-dienenitrile
- Molecular formula:
- C11H17N
- IUPAC Name:
- (3E/6E)-3,7-dimethylnona-3,6-dienenitrile
- Test material form:
- liquid
Constituent 1
Constituent 2
Constituent 3
Constituent 4
impurity 1
impurity 2
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): Lemonile
- Substance type: Clear colourless liquid
- Physical state: Liquid
Test animals / tissue source
- Species:
- rabbit
- Strain:
- not specified
- Details on test animals or tissues and environmental conditions:
- No data available
Test system
- Vehicle:
- other: Propylene glycol
- Controls:
- yes, concurrent no treatment
- Amount / concentration applied:
- TEST MATERIAL
- Volume applied: 0.1 mL
- Concentration: 0.5 % in propylene glycol. - Duration of treatment / exposure:
- Test material applied once.
- Observation period (in vivo):
- 7 days (observations at 24 hrs, 48 hrs, 72 hrs, 96 hrs and 7 d).
- Number of animals or in vitro replicates:
- 3
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing: None
SCORING SYSTEM:
- Draize scale for scoring ocular lesions.
- Cornea, iris and conjunctiva examined.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Remarks:
- opacity
- Basis:
- mean
- Remarks:
- All animals
- Time point:
- 24/48/72 h
- Score:
- 0
- Irritation parameter:
- iris score
- Basis:
- mean
- Remarks:
- All animals
- Time point:
- 24/48/72 h
- Score:
- 0
- Irritation parameter:
- conjunctivae score
- Remarks:
- redness
- Basis:
- mean
- Remarks:
- All animals
- Time point:
- 24/48/72 h
- Score:
- 0
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Remarks:
- All animals
- Time point:
- 24/48/72 h
- Score:
- 0
- Irritant / corrosive response data:
- No animals showed any reaction to the test substance.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Lemonile was not irritating to the eyes.
- Executive summary:
Instillation of 0.1 mL of the test material into the right eye of each of three rabbits did not produce any irritation in any of the treated eyes.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
