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Toxicological information

Carcinogenicity

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Description of key information

No carcinogenicity data available.

Key value for chemical safety assessment

Additional information

Thiodiglycol did not induce mutations in bacteria or mouse lymphoma cells with or without addition of a metabolic activation system. At high dose levels which resulted in cytotoxic effects, thiodiglycol induced chromosome aberrations in vitro, both in the presence and the absence of a metabolic activation system. No clastogenic activity was detected in the mouse bone marrow micronucleus assay at oral doses up to and including 2000 mg/kg bw. It is therefore concluded that the clastogenic effects seen in vitro are not expressed in vivo. Based on the available genotoxicity data, there is no hint for any carcinogenic potential.

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