Registration Dossier

Administrative data

Description of key information

Key value for chemical safety assessment

Skin sensitisation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not sensitising)
Additional information:

In a guinea pig maximization test (BASF 1991) according to the current guidelines a test group of 10 animals received 5 % thiodiglycol in aqueous solution for intradermal induction, followed by percutaneous induction with 0.3 g undiluted thiodiglycol under occlusive dressing for 48 hours. For challenge 0.15 g thiodiglycol (75 % solution in water; no irritating effect at this concentration) was applied to the intact skin for 24 hours (occlusive). The challenge resulted in no skin reaction, neither in thiodiglycol treated animals nor in negative controls. All 20 animals treated with the positive control substance 1-chloro-2,4-dinitrobenzene showed sensitization effects. In a further guinea pig maximization test (Elf Aquitaine 1998) according to OECD guideline 406 no cutaneous reactions were observed after the challenge application. Conclusion: In the guinea pig maximization test no sensitising effects were detected. No data are available on humans.


Migrated from Short description of key information:
A documentation and evaluation of available data on this endpoint is presented in:
Thiodiglycol, SIDS Initial Assessment Report for SIAM 19, final version 10/2006.

Justification for classification or non-classification

Classification for sensitisation is not warranted according to the criteria of EU Directive 67/548/EEC and EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008.