Registration Dossier

Toxicological information

Acute Toxicity: dermal

Currently viewing:

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Secondary literature

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
2,2'-thiodi-ethanol
Author:
RTECS, Registry of toxic effects of chemical substances
Year:
2008
Reference Type:
publication
Title:
Toxicity assessment of thiodiglycol
Author:
Reddy G, Major MA, Leach GJ
Year:
2005
Bibliographic source:
Int J Toxicol 24:435–442

Materials and methods

Principles of method if other than guideline:
LD50 in rabbits after dermal application
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
no further data

Test animals

Species:
rabbit
Strain:
not specified
Sex:
not specified

Administration / exposure

Type of coverage:
not specified
Vehicle:
not specified
Duration of exposure:
no data
Doses:
no data
No. of animals per sex per dose:
no data
Control animals:
not specified

Results and discussion

Preliminary study:
no data
Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
23 600 mg/kg bw

Any other information on results incl. tables

original value: LD50 = 20 ml/kg

no further data available

Applicant's summary and conclusion

Conclusions:
LD50 in rabbits after dermal application is 23600 mg/kg bw.
Executive summary:

Secondary literature.

LD50 in rabbits after dermal application is 23600 mg/kg bw.