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Administrative data

Description of key information

A documentation and evaluation of available data on this endpoint is presented in:
Thiodiglycol, SIDS Initial Assessment Report for SIAM 19, final version 10/2006.

Key value for chemical safety assessment

Acute toxicity: via oral route

Endpoint conclusion
Dose descriptor:
LD50
Value:
11 800 mg/kg bw

Additional information

Thiodiglycol is of low acute toxicity in mammals.

Oral application

An acute approximate lethal dose determination was performed in male and female rats by Angerhofer et al. (1997). Eight animals of each sex were given neat thiodiglycol (purity ≥ 95 %), one dose per rat, by gavage at dose levels of 579, 869, 1304, 1956, 2933, 4400, 6600, or 9900 mg/kg bw. No toxic effects or deaths were produced in female rats. The male rat given 9900 mg/kg bw was slightly lethargic starting 1 hour post-treatment, but recovered within 4 hours. No other effects were noted.

In a poorly documented study, dyspnoea and dizziness were observed as clinical signs of toxicity in rats after gavage of 11 800 mg/kg bw (= the reported approximative LD50 value). Gross pathology after the 7-day post-exposure period showed pancreas bleeding (BASF AG, 1966).

Dermal application

No assignable acute toxicity data were available for the dermal route. The LD50 in rabbits was reported to be 23600 mg/kg bw (secondary literature; RTECS 2008).

Inhalation

In the Rat Inhalation Hazard Test, no mortality was reported after 8 h exposure to a saturated atmosphere at room temperature. Immediately after the start of exposure, the animals showed attempts to escape. Irritation of the mucous membranes was observed 1 h after start of exposure. Three out of 12 rats showed chronic bronchitis at necropsy, but these findings were judged to be not treatment related (BASF AG, 1966 & 2004b).

Justification for classification or non-classification

The acute oral LD50 value in rats was 11800 mg/kg bw, with depression of the central nervous system as the main clinical sign at doses near to or exceeding the LD50 value. No assignable data are available on acute dermal toxicity. The inhalation of the saturated vapour for 8 h resulted in no mortality. Therefore, classification for acute toxicity is not warranted according to the criteria of EU Directive 67/548/EEC and EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008.