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Ecotoxicological information

Long-term toxicity to fish

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Reference
Endpoint:
long-term toxicity to fish, other
Type of information:
calculation (if not (Q)SAR)
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
accepted calculation method
Justification for type of information:
Data is from computational model developed by USEPA
Qualifier:
according to guideline
Guideline:
other: Modeling database
Principles of method if other than guideline:
Long term toxicity study of test chemical were studied on the mortality rate of fish.
GLP compliance:
no
Analytical monitoring:
no
Vehicle:
no
Test organisms (species):
other: Fish
Test type:
flow-through
Water media type:
saltwater
Total exposure duration:
28 d
Test temperature:
25 Deg.C
Reference substance (positive control):
no
Key result
Duration:
28 d
Dose descriptor:
NOEC
Effect conc.:
0.164 mg/L
Nominal / measured:
estimated
Conc. based on:
test mat.
Basis for effect:
mortality
Remarks on result:
other: Neutral Organics
Validity criteria fulfilled:
not specified
Conclusions:
Based on the EPI Suite ECOSAR, the 28 d NOEC value was estimated to be 0.164 mg/l on Fish for test substance on the basis of no mortality effects.
Executive summary:

Using the EPI Suite ECOSAR, the long term toxicity on fish was predicted for test substance. On the basis of no effects observed in a flow-through system, the no observed effect concentration (NOEC) value for the substance is estimated to be 0.164 mg/l for saltwater fish for 28 d duration. Thus on the basis of NOEC value, chemical consider to be toxic and classified in aquatic chronic category 2 as per the CLP classification criteria.

Description of key information

Using the EPI Suite ECOSAR, the long term toxicity on fish was predicted for test substance. On the basis of no effects observed in a flow-through system, the no observed effect concentration (NOEC) value for the substance is estimated to be 0.164 mg/l for saltwater fish for 28 d duration. Thus on the basis of NOEC value, chemical consider to be toxic and classified in aquatic chronic category 2 as per the CLP classification criteria.

Key value for chemical safety assessment

Fresh water fish

Fresh water fish
Effect concentration:
0.164 mg/L

Additional information

Various experimental and predicted studies available for the test chemical and functionally similar read across chemical were reviewed to determine the toxic nature of test chemical on the fish. The studies are as mentioned below:

 

Using the EPI Suite ECOSAR, the long term toxicity on fish was predicted for test substance. On the basis of no effects observed in a flow-through system, the no observed effect concentration (NOEC) value for the substance is estimated to be 0.164 mg/l for saltwater fish for 28 d duration. Thus on the basis of NOEC value, chemical consider to be toxic and classified in aquatic chronic category 2 as per the CLP classification criteria.

 

Above data was supported by the second study from authoritative database. Aim of this study was to determine the prolonged effect of test chemical on the freshwater fish. Test conducted for 14 days under semi-static system. After the exposure of test chemical with fish for 14 days, LC50 was determine at 0.78 mg/l and no effect (NOEC) were observed at 0.14 mg/l. Thus based on the LC50 value, chemical consider to be toxic and classified as aquatic chronic 2 as per the CLP classification criteria.

 

Objective of this third study was to determine the prolonged effect of test chemical on the fish by providing the exposure period of 14 days. After the exposure of chemical with fish for 14 days, no effects were observed on fish at concentration 0.75 mg/l. Thus on the basis of NOEC value, chemical consider to be toxic and classified as aquatic chronic 2 as per the CLP classification criteria.

 

Thus by considering the above effects, chemical consider to be toxic and classified as aquatic chronic 2 as per the CLP classification criteria.