Registration Dossier
Registration Dossier
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EC number: 222-079-2 | CAS number: 3338-24-7
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
- Endpoint:
- activated sludge respiration inhibition testing
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- Please refer to Read Across Statement attached in Section 13
- Reason / purpose for cross-reference:
- read-across source
- Reference substance (positive control):
- yes
- Remarks:
- benzoic acid, sodium salt
- Duration:
- 28 d
- Dose descriptor:
- other: oxygen consumption
- Effect conc.:
- 30.6 other: % of ThOD
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- other: oxygen elektrode
- Basis for effect:
- inhibition of total respiration
- Remarks:
- respiration rate
- Validity criteria fulfilled:
- yes
- Conclusions:
- In biodegradation test OECD 301 D the oxygen consumption corresponded to 30.6% of the ThOD after 14 days in the toxicity control. Therefore the tested substance can be considered not inhibitory to the inoculum according to this test guideline
Remark: The test solution contains NaOH due to the production method.
Due to the similarity of the target substance, EP1-Na, and the source substance, IBP1-Na, the result of this study is assessed to be adequate in order to fulfil the requirements of REACH. The read-across approach is further described in the document “Justification of read across from CAS No 53378-51-1 IBP1-Na (source) to CAS No 3338-24-7, EP1-Na (target)” attached in “Point 13 Assessment reports”. - Executive summary:
The test was performed according to the OECD guideline 301D under GLP compliance. The test was done on domestic sewage for 28days. The oxygen consumption corresponded to 30.6% of the ThOD after 14 days in the toxicity control. Therefore the tested substance can be considered not inhibitory to the inoculum
Reference
Description of key information
Read-across: OECD 301 D, 28 days, domestic sewage: oxygen consumption corresponded to 30.6% of the ThOD after 14 days in the toxicity control. Therefore the tested substance can be considered not inhibitory to the inoculum.
Key value for chemical safety assessment
Additional information
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