1,2-dimethylimidazole

Acute Toxicity: dermal

Administrative data

Endpoint:

acute toxicity: dermal

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

comparable to guideline study with acceptable restrictions

Remarks:

Meets generally accepted scientific standards, well documented and acceptable for assessment

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1979

Report date:

1979

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 402 (Acute Dermal Toxicity)

Version / remarks:

prior to the adoption of OECD402 in 1981

GLP compliance:

no

Test type:

standard acute method

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

1,2-dimethylimidazole

EC Number:

217-101-2

EC Name:

1,2-dimethylimidazole

Cas Number:

1739-84-0

Molecular formula:

C5H8N2

IUPAC Name:

1,2-dimethyl-1H-imidazole

Details on test material:

- Name of test material (as cited in study report): 1,2-Dimethylimidazol
- Substance number: 77/683

Test animals

Species:

rabbit

Strain:

Vienna White

Sex:

male/female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Source: M.GAUKLER (6050 Offenbach, Germany)
- Weight at study initiation: 2.9 kg
- Diet: Ssniff K, standard diet for rabbits and guinea pigs (Firma INTERMAST GMBH, Soest), ad libitum
- Water: ad libitum

Administration / exposure

Type of coverage:

occlusive

Vehicle:

water

Details on dermal exposure:

TEST SITE
15 to 24 hrs before treatment, dorsal and lateral parts of the body of the animals were shaved with an electric clipper exposing an area of approximatly 50 cm2

- Type of wrap if used: aluminium foil fixed with adhesive tape

REMOVAL OF TEST SUBSTANCE
- Washing: with warm water or a water/Lutrol mixture
- Time after start of exposure: 24 hours

TEST MATERIAL
- Concentration: 50 % solution

Duration of exposure:

24 hours

Doses:

200 mg/kg bw

No. of animals per sex per dose:

5

Control animals:

no

Details on study design:

- Duration of observation period following administration: 8 days
- Frequency of observations and weighing: after 1, 24 and 48 hours and on day 8
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs and local skin irritaion

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LD50

Effect level:

> 200 mg/kg bw

Based on:

test mat.

Mortality:

None of the animals died during the observation period.

Clinical signs:

other: No abnormal observations were reported.

Gross pathology:

No abnormal observations were reported.

Other findings:

24 hours after application the animals show a mild primary skin irritation which remained consistent for almost 48 hours.