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EC number: 212-769-1 | CAS number: 868-14-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1982
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 984
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- EU Method B.13/14 (Mutagenicity - Reverse Mutation Test Using Bacteria)
- Deviations:
- yes
- Remarks:
- (No metabolic activation employed)
- GLP compliance:
- no
- Remarks:
- no data
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- Potassium hydrogen tartrate
- EC Number:
- 212-769-1
- EC Name:
- Potassium hydrogen tartrate
- Cas Number:
- 868-14-4
- Molecular formula:
- C4H6O6.K
- IUPAC Name:
- potassium 3-carboxy-2,3-dihydroxypropanoate
1
- Specific details on test material used for the study:
- 100% purity reported
Method
Species / strainopen allclose all
- Species / strain / cell type:
- S. typhimurium TA 1535, TA 1537, TA 98 and TA 100
- Species / strain / cell type:
- S. typhimurium, other: TA 92 and TA 94
- Metabolic activation:
- with and without
- Metabolic activation system:
- S9 fraction prepared from livers of pretreated rats with PCB compund Kanechlor KC-400
- Test concentrations with justification for top dose:
- Reported 6 concentrations. Maximum concentration tested is 0.5 mg/plate.
- Vehicle / solvent:
- Diluted in a solution of 0.1 N sodium hydroxyde.
Controls
- Untreated negative controls:
- yes
- Negative solvent / vehicle controls:
- yes
- Positive controls:
- yes
- Positive control substance:
- other: no data
- Remarks:
- Details nos providad in paper, althogh numerous positive substances are reported.
- Details on test system and experimental conditions:
- Cells cultured overnight were pre-incubated with both the test sample and the S-9 mix for 20 min at 37°C before plating. Duplicate plates were used for e ach of six different concentrations of the sample.
The number of revertant (his +) colonies was scored after incubation at 37°C for 2 days. - Evaluation criteria:
- The result was considered positive if the number of colonies found was twice the number in the control (exposed to the appropriate solvent or untreated).
Results and discussion
Test resultsopen allclose all
- Species / strain:
- S. typhimurium TA 1535
- Remarks:
- TA 1537, TA 98 and TA 100
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- no cytotoxicity
- Vehicle controls validity:
- valid
- Untreated negative controls validity:
- valid
- Positive controls validity:
- other: no data
- Species / strain:
- S. typhimurium, other: TA 92 and TA 94
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- no cytotoxicity
- Vehicle controls validity:
- valid
- Untreated negative controls validity:
- valid
- Positive controls validity:
- other: no data
- Additional information on results:
- Interpretation of results: Negative
- Remarks on result:
- other: Test system: all strains/cell types tested
Applicant's summary and conclusion
- Conclusions:
- The substance potassium bitartrate (potassium hydrogen tartrate) was tested up to a maximum concentration of 0.5 mg/ml on Salmonella strains TA 1535, TA 1537, TA 98, TA 92, TA 94 and TA 100, with and without metabolic activation as part of a programme sponsored by the Japanese Ministry of Health and Welfare to test common food additives. Results obtained on all strains tested at the maximum concentrations tested were negative.
- Executive summary:
The substance potassium bitartrate (potassium hydrogen tartrate) was tested up to a maximum concentration of 0.5 mg/ml on Salmonella strains TA 1535, TA 1537, TA 98, TA 92, TA 94 and TA 100, with and without metabolic activation as part of a programme sponsored by the Japanese Ministry of Health and Welfare to test common food additives. Results obtained on all strains tested at the maximum concentrations tested were negative.
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