Registration Dossier

Toxicological information

Endpoint summary

Currently viewing:

Administrative data

Link to relevant study record(s)

Description of key information

The physico-chemical properties of the substance suggest that it may be absorbed by oral route while inhalation exposure may not occur.

Key value for chemical safety assessment

Bioaccumulation potential:
low bioaccumulation potential

Additional information

The physico-chemical properties of the substance suggest that it should be available for absorption, i.e.: it has a low water solubility and a fairly high partition coefficient. Its low vapour pressure value suggests that it would not be a hazard by inhalation.

The histopathological effects on the liver and kidney observed in the sub-acute oral study and considered as a strong adaptative response demonstrated that the test material is absorbed via the gastro-intestinetractand distributed to at least the major organs.

 

The increase in water consumption and the urinary changes observed in the sub-acute study indicated that the kidney is a major route of excretion of the test material and/or its metabolites. The increase in hepatic bile pjgments without any change in haematology, and the cholangitis, suggested that a proportion of test material or its metabolites is eliminated by biliary excretion.

 

The increase in liver weights and the hepatocytic hypertrophy observed in the sub-acute oral study indicate that the test substance is metabolised in the liver.