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Environmental fate & pathways

Endpoint summary

Administrative data

Description of key information

Additional information

For evaluating the stability of the test substance (Amber Core, P#620), two valid studies according to theDirective 84/449/EEC Part C Method C.07, performed underGLP are available. The abiotic degradation of Amber core was assessed in two parts: the results ofthe preliminary study (supporting study) were provided in the first report (Sunakawa, 1992) and the results of the definitive study (key study) were provided in the second report (Sunakawa, 1994).

In the preliminary study (Sunakawa, 1992), the results indicate that a 25°C, Amber Core possesses a half-life between 1 day and 1 year at pH 4, 7 and 9. This indicated the need for further testing at pHs 4, 7 and 9 using the extended tests as described in the Directive.

For the definitive study (Sunakawa, 1994), the hydrolysis reaction of Amber core at 25°C and pH 4 occurred with a half-life of 216 hours (9 days). At pH 7 and 25°C, the hydrolysis reaction of Amber core had an estimated half-life of 648 hours (27 days) and at pH 9 and 25°C, at an estimated half-life of 609 hours (25 days).

Taking the longest half-life for hydrolysis into consideration, the half-life of 648 hours, equivalent to 27 days at 25°C and pH 7 was used as the key value for chemical safety assessment.