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EC number: 257-288-8 | CAS number: 51566-62-2
Endpoint summary
Administrative data
Description of key information
Acute oral toxicty: LD50=4490 mg/kg bw (Consumer Product Testing Company, 1979).
Acute inhalation toxicty: LC50 > 4.9 mg/L air (BASF, 1982).
Acute dermal toxicty: LD50 >5.0 mg/kg bw (RIFM, 1977).
Key value for chemical safety assessment
Additional information
Acute oral toxicity:
In the chosen key study for acute oral toxicity ,3,7-dimethyloct-6-enenitrile was dosed to Wistar strain albino rats (3 per sex per dose) at 3150, 3960, 4460, 6300 and 7940 mg/kg (Consumer Product Testing Company, 1979). The LD50 was determined to be 4490 mg/kg bw.
In a supporting study, 10 rats per dose were observed for 14 days for mortality and toxic signs after single oral administration of 3,7-dimethyloct-6-enenitrile (Moreno, 1977). The LD50 was determined to be 5300 mg/kg bw.
Acute inhalation toxicity:
In the chosen key study for acute inhalation toxicity, Wistar rats (10/sex) were administered 3,7-dimethyloct-6-enenitrile at 4.9 mg/L by inhalation for 4 hours followed by a 14-day observation period (BASF, 1982). No mortality was observed. During exposure animals showed aqueous discharge from nose and salivation. After exposure, aqueous, slight discharge from noses, salivation, reddened ears and limbs was observed. These effects were absent after one day. A normal weight gain was observed and no abnormal findings were made at necropsy. The LC50 was >4.9 mg/L air.
Acute dermal toxicity:
In the chosen key study for acute dermal toxicity, 10 rabbits were dosed with 5000 mg/kg bw 3,7-dimethyloct-6-enenitrile (RIFM 1977). No animals died and no clinical signs were observed besides mild redness and mild to moderate edema. Fecal matter anogenitally, pocked and mottled kidney, and blue-grey spleen was observed. The LD50 was determined to be greater than 5000 mg/kg bw.
Justification for classification or non-classification
The present data on acute toxicity do not fulfill the criteria laid down in 67/548/EEC and regulation (EU) 1272/2008, and therefore, a non-classification is warranted. According to UN-GHS, the test substance needs to be classified as acute oral toxicant (Category 5).
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