Registration Dossier
Registration Dossier
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EC number: 232-136-3 | CAS number: 7787-93-1
Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on fertility
Description of key information
There are no oral, inhalation or dermal reproductive toxicity studies available for dichloro(3-chloropropyl)methylsilane. Data waivers are in place for this endpoint (see data waiver justification toxicity to reproduction in Section 5.6.3).
Effect on fertility: via oral route
- Endpoint conclusion:
- no study available
Effect on fertility: via inhalation route
- Endpoint conclusion:
- no study available
Effect on fertility: via dermal route
- Endpoint conclusion:
- no study available
Additional information
There are no oral, inhalation or dermal reproductive toxicity studies available for dichloro(3-chloropropyl)methylsilane. Data waivers are in place for this endpoint (see data waiver justification toxicity to reproduction in Section 5.6.3).
Limited data are available regarding the reproduction and development of animals following oral, dermal or inhalation exposure to hydrogen chloride or hydrochloric acid, however, protons and chloride ions both exist as normal constituents of body fluid in animals, hence low concentrations of hydrogen chloride appear not to cause adverse effects in animals. Therefore, hydrochloric acid would not contribute to any reproductive toxicity (fertility or developmental) effects at the dose levels tested.
Effects on developmental toxicity
Description of key information
There are no oral, inhalation or dermal developmental toxicity studies available for dichloro(3-chloropropyl)methylsilane. Data waivers are in place for this endpoint (see data waiver justification for developmental toxicity in Section 5.6.3).
Effect on developmental toxicity: via oral route
- Endpoint conclusion:
- no study available
Effect on developmental toxicity: via inhalation route
- Endpoint conclusion:
- no study available
Effect on developmental toxicity: via dermal route
- Endpoint conclusion:
- no study available
Additional information
There are no oral, inhalation or dermal developmental toxicity studies available for dichloro(3-chloropropyl)methylsilane. Data waivers are in place for this endpoint (see data waiver justification for developmental toxicity in Section 5.6.3).
Limited data are available regarding the reproduction and development of animals following oral, dermal or inhalation exposure to hydrogen chloride or hydrochloric acid, however, protons and chloride ions both exist as normal constituents of body fluid in animals, hence low concentrations of hydrogen chloride appear not to cause adverse effects in animals. Therefore hydrochloric acid would not contribute to any reproductive toxicity (fertility or developmental) effects at the dose levels tested.
Justification for classification or non-classification
The available data indicate that dichloro(3-chloropropyl)methylsilane
does not need to be classified for toxicity to reproduction (fertility or developmental toxicity) according to Regulation (EC) No 1272/2008.
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
