Registration Dossier
Registration Dossier
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EC number: 232-136-3 | CAS number: 7787-93-1
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
48 h EC50: 295 mg/l D. magna (read-across from CAS 13501 -76 -3), or 216 mg/l when expressed in terms of the silanol hydrolysis product (3-chloropropyl)methylsilanediol.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 216 mg/L
Additional information
There are no reliable data for the short-term effects of the registered substance on aquatic invertebrates. A 48-h EC50 value of 295 mg/l and a 48-h NOEC value of 106 mg/l have been determined for the effects of (3-chloropropyl)diethoxymethylsilane (CAS 13501-76-3) on mobility of Daphnia magna. It is likely that the test organisms were primarily exposed to the hydrolysis products of the substance due to the duration of the test media preparation (18 hours stirring) and the study regime (static). The results may be expressed in terms of concentration of the hydrolysis product, (3-chloropropyl)methylsilanediol, by applying a molecular weight correction: (MW of silanol = 154.67 / MW of parent = 210.78) * EC50 = 295 mg/l = 216 mg/l as (3-chloropropyl)methylsilanediol.
The following data are used to support the read-across:
A 48-h EC50 value of >100 mg/l has however been obtained for the structurally-analogous read-across substance (3-chloropropyl)dimethoxymethylsilane, CAS 18171-19-2. The organisms would have been predominantly exposed to the hydrolysis product, (3-chloropropyl)methylsilanediol. The results may be expressed in terms of concentration of the hydrolysis product, (3-chloropropyl)methylsilanediol, by applying a molecular weight correction: (MW of silanol = 154.67 / MW of parent = 182.72) * EC50 = >100 mg/l = >85 mg/l as (3-chloropropyl)methylsilanediol.
The registered substance and CAS 18171-19-2 both hydrolyse very rapidly in water to (3-chloropropyl)methylsilanediol. Although (3-chloropropyl)diethoxymethylsilane (CAS 13501-76-3) has a slower hydrolysis half-life than the registered substance, the long test solution preparation time for the short-term invertebrate study with this substance, indicates that the test organisms would have been predominantly exposed to the hydrolysis products. This test determined a definitive, non-limit EC50 value for the effects of the hydrolysis product on mortality ofDaphnia magna. Therefore, the study with CAS 13501-76-3 has been selected as key.
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