Registration Dossier
Registration Dossier
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EC number: 937-417-0 | CAS number: -
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Additional information
The source substance Ashes (residues), when applied to the skin or to the mucous membrane (conjunctivae) of experimental animals, elicited only slight effects at the site of application that disappeared quickly. The substance is not irritant nor sensitizer. Presumably the substance does not enter the body through these routes.
After the acute exposition through the stomach of rats (2000 mg/kg) no digestive tract irritation or other clinical or pathological symptoms were observed. This experiment did not allow the estimation if the substance is absorbed during such an exposition design.
After repeated oral exposure there is some evidence in favour of the substance penetration through stomach mucosa and entering distant compartment of the body a as to pituitary gland, prostate gland or uterus. In reproduction study the effect on fertility indices was detected (increased post-implantation loss and decrease in the number of pups in litter).
The source substance Ashes (residues) could penetrate the body more readily during the inhalation or intratracheal instillation. But also the effects observed in these studies were mostly local influencing the histological structure of pulmonary tissue and the local immune response. The substance is absorbed into blood circulation and influences the blood biochemical and/or haematological parameters. Scarcely the distant effects are reported as those in the bone marrow or the liver. These distant effects are dependent on the physical and chemical constitution of the particulate matter and on the conditions of exposure. But at the optimal conditions the substance could reach also the uterus and elicit negative influence on the foetus development.
Based on the similarity of the source material, Ashes (residues), and the target material, Ashes (residues), nonhazardous municipal solid waste, may be assumed identical or similar toxicokinetic behaviour both materials.
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