Registration Dossier
Registration Dossier
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EC number: 600-687-2 | CAS number: 105839-18-7
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
The substance MonoFA_TETA_PAA_BADGE_BGE_Adduct has been tested in three GLP in-vitro mutagenicity test systems
- Ames test according to OECD 471 (s. typhimurium strains TA98, TA100, TA102, TA1535 and TA1537),
- Chromosome aberration test according to OECD 473 (cultured human peripheral blood lymphocytes) and
- Mouse lymphoma test according to OECD 476 (mouse lymphoma L5178Y cells),
and was found negative in all three in-vitro test systems, with and without metabolic activation.
Thus, the substance is not expected causing gene mutations an no further (in-vivo) tests are required.
Short description of key information:
The substance MonoFA_TETA_PAA_BADGE_BGE_Adduct has been tested in three in-vitro mutagenicity test systems (Ames test according to OECD 471, Chromosome aberration test according to OECD 473 and Mouse lymphoma test according to OECD 476, all under GLP) and was found negative in all three in-vitro test systems, with and without metabolic activation. Thus, the substance is not expected causing gene mutations an no further tests are required.
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
MonoFA_TETA_PAA_BADGE_BGE_Adduct was found negative in three in-vitro mutagenicity test systems (Ames test according to OECD 471, Chromosome aberration test according to OECD 473 and Mouse lymphoma test according to OECD 476, all under GLP) for inducing gene mutations an thus classification according to CLP (Regulation EC No 1272/2008) or DSD (Directive 67/548/EEC) is not required.
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