Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
sensitisation data (humans)
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: well documented and scientifically acceptable publication

Data source

Reference
Reference Type:
publication
Title:
Isocyanate asthma: respiratory symptoms due to 1,5-naphthylene diisocyanate
Author:
Harries MG et al.
Year:
1979
Bibliographic source:
Thorax 34: 762-766

Materials and methods

Type of sensitisation studied:
respiratory
Study type:
study with volunteers
Principles of method if other than guideline:
Bronchial provocation testing with MDI, TDI, NDI, histamine and exercise according to the method described by O'Brien et al. (Clinical Allergy 9: 1-6, 1979).
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
1,5-naphthylene diisocyanate
EC Number:
221-641-4
EC Name:
1,5-naphthylene diisocyanate
Cas Number:
3173-72-6
Molecular formula:
C12H6N2O2
IUPAC Name:
1,5-diisocyanatonaphthalene
Details on test material:
no further information

Method

Type of population:
occupational
Controls:
no data
Route of administration:
inhalation

Results and discussion

Any other information on results incl. tables

2/3 patients with occupationally related asthma had non-immediate reactions by exposure to NDI only; 1/3 of the same patients had a

dual reaction provoked by NDI (no reaction to MDI, TDI and exercise).

Applicant's summary and conclusion