Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 920-632-9 | CAS number: -
Toxicological Summary
Administrative data
Workers - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no-threshold effect and/or no dose-response information available
Acute/short term exposure
- Hazard assessment conclusion:
- no-threshold effect and/or no dose-response information available
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no-threshold effect and/or no dose-response information available
Acute/short term exposure
- Hazard assessment conclusion:
- no-threshold effect and/or no dose-response information available
DNEL related information
Workers - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- exposure based waiving
Acute/short term exposure
- Hazard assessment conclusion:
- exposure based waiving
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- exposure based waiving
Acute/short term exposure
- Hazard assessment conclusion:
- exposure based waiving
Workers - Hazard for the eyes
Additional information - workers
Nickel slag is a complex metal containing substance. It mainly contain iron silicate and silicates of aluminum and calcium. Traces of metals exist in metal, mineral form or included in silicate phases.
The toxicity and classification is therefore related to:
- Amount of metals present (%)
- Speciation of metals
- Degree to which the metal constituents react with water / biological fluids and release soluble, potentially bio available ionic and other metal bearing species.
- Rules for classification of mixtures as defined in the CLP regulation (2009)
Classification derived using read accross approach based on high quality test data on skin irritation, eye irritation, acute toxicity via oral and dermal route, bacterial gene mutation test and bacterial survival test for the analogue substance slag, copper smelting
Results demonstrate that:
- Copper slag is not skin irritant. The absence of irritation effects furthermore excludes the possibility for corrosion, defined as serious damage of tissues throughout the skin thickness.
- Copper slag is not harmful and not toxic via oral and dermal route.
- Copper slag is not mutagenic and does not affect bacteria survival.
Based on this outcome for the source substance, the absence of skin irrittaion, acute toxicity via oral and dermal route and mutagenicity is predicted for the target subtance nickel slag.
Classification of nickel slag was furthermore derived based on the rules for mixtures (CLP regulation).
The assessed samples are representative for typical nickel slags and fall within the concentration ranges outlined under IUCLID section 1.2.
Data from in vitro bio-accessibility tests in biological fluids (gastric and sweat) are further used to refine /confirm the classification.
Conclusively based on consideration of toxicity data, chemical composition, speciation and reduced bio-accessibility, nickel slags do not need classification for human health hazards.
A summary of the human health classification is attached.
Detailed explanation and justification are provided in records for every endpoint
General Population - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no-threshold effect and/or no dose-response information available
Acute/short term exposure
- Hazard assessment conclusion:
- no-threshold effect and/or no dose-response information available
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no-threshold effect and/or no dose-response information available
Acute/short term exposure
- Hazard assessment conclusion:
- no-threshold effect and/or no dose-response information available
DNEL related information
General Population - Hazard via dermal route
Systemic effects
Acute/short term exposure
- Hazard assessment conclusion:
- exposure based waiving
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- exposure based waiving
Acute/short term exposure
- Hazard assessment conclusion:
- exposure based waiving
General Population - Hazard via oral route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no-threshold effect and/or no dose-response information available
Acute/short term exposure
- Hazard assessment conclusion:
- no-threshold effect and/or no dose-response information available
DNEL related information
General Population - Hazard for the eyes
Additional information - General Population
Nickel slag is a complex metal containing substance. It mainly contain iron silicate and silicates of aluminum and calcium. Traces of metals exist in metal, mineral form or included in silicate phases.
The toxicity and classification is therefore related to:
- Amount of metals present (%)
- Speciation of metals
- Degree to which the metal constituents react with water / biological fluids and release soluble, potentially bio available ionic and other metal bearing species.
- Rules for classification of mixtures as defined in the CLP regulation (2009)
Classification derived using read accross approach based on high quality test data on skin irritation, eye irritation, acute toxicity via oral and dermal route, bacterial gene mutation test and bacterial survival test for the analogue substance slag, copper smelting
Results demonstrate that:
- Copper slag is not skin irritant. The absence of irritation effects furthermore excludes the possibility for corrosion, defined as serious damage of tissues throughout the skin thickness.
- Copper slag is not harmful and not toxic via oral and dermal route.
- Copper slag is not mutagenic and does not affect bacteria survival.
Based on this outcome for the source substance, the absence of skin irrittaion, acute toxicity via oral and dermal route and mutagenicity is predicted for the target subtance nickel slag.
Classification of nickel slag was furthermore derived based on the rules for mixtures (CLP regulation).
The assessed samples are representative for typical nickel slags and fall within the concentration ranges outlined under IUCLID section 1.2.
Data from in vitro bio-accessibility tests in biological fluids (gastric and sweat) are further used to refine /confirm the classification.
Conclusively based on consideration of toxicity data, chemical composition, speciation and reduced bio-accessibility, nickel slags do not need classification for human health hazards.
A summary of the human health classification is attached.
Detailed explanation and justification are provided in records for every endpoint
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
