Registration Dossier
Registration Dossier
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EC number: 272-712-1 | CAS number: 68909-77-3 The residuum from the reaction of diethylene glycol and ammonia. It consists predominantly of morpholine-based derivatives such as [(aminoethoxy)ethyl]morpholine, [(hydroxyethoxy)ethyl]morpholine, 3-morpholinone, and 4,4'-(oxydi-2,1-ethanediyl)bis[morpholine].
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study report meets generally acceptable scientific principles
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 969
- Report date:
- 1969
Materials and methods
- Principles of method if other than guideline:
- Study to determine the acute i.p. toxicity ot the test substance in mice
- GLP compliance:
- no
Test material
- Reference substance name:
- Ethanol, 2,2'-oxybis-, reaction products with ammonia, morpholine derivs. residues
- EC Number:
- 272-712-1
- EC Name:
- Ethanol, 2,2'-oxybis-, reaction products with ammonia, morpholine derivs. residues
- Cas Number:
- 68909-77-3
- Molecular formula:
- Not applicable (UVCB)
- IUPAC Name:
- 2-(2-hydroxyethoxy)ethan-1-ol; 2-[1-(morpholin-4-yl)ethoxy]ethan-1-amine; 2-{2-[bis(2-hydroxyethyl)amino]ethoxy}ethan-1-ol; 4-{2-[2-(morpholin-4-yl)ethoxy]ethyl}morpholine; morpholin-3-one
- Details on test material:
- - Name of test material (as cited in study report): Morpholin-Rueckstand (morpholin remainder)
- Substance type: remainder mixture
- Physical state: liquid
- Analytical purity: no data
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- not specified
- Sex:
- male/female
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- water
- Details on exposure:
- 2%-20%
- Doses:
- 200-1600 µL/kg (=ca. 212-1700 mg/kg; calculated with a density of 1.06 g/mL)
- No. of animals per sex per dose:
- 10
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 7 days
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- ca. 742 mg/kg bw
- Remarks on result:
- other: original data: ca. 0.7 mL/kg bw
- Mortality:
- no mortality up to 400 µL/kg bw
500 µL/kg bw: 2/20
640 µL/kg bw: 3/20
800 and 1600 µL/kg bw: 20/20 - Clinical signs:
- 800 and 1600 µL/kg bw: directly after injection tremor, convulsion, stretching, crying, sunken flanks, high stepping and slightly staggering gait, avoidance of abdominal position, agitation, closed eye lids; intense stretching convulsions in agony
<= 640 µL/kg bw: symptoms as decribed for higher doses but in weaker extension; reversible within at least 6 days - Body weight:
- not measured at study termination
- Gross pathology:
- Animals that died: Intestines filled with bloody liquids, lobular pataatern visible;4* intraabdominal adhesions
Sacrificed animals: in most of the animals intrabdominal adhesions, 12* truncated liver edges
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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