p-tert-butylphenyl 1-(2,3-epoxy)propyl ether

Eye irritation

Administrative data

Endpoint:

eye irritation: in vivo

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: The study was conducted according to the O.E.C.D. test guideline 405 with GLP compliance.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2011

Report date:

2011

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 405 (Acute Eye Irritation / Corrosion)

Deviations:

no

GLP compliance:

yes

Test material

Test material information

Constituent 1

Reference substance name:

p-tert-butylphenyl 1-(2,3-epoxy)propyl ether

EC Number:

221-453-2

EC Name:

p-tert-butylphenyl 1-(2,3-epoxy)propyl ether

Cas Number:

3101-60-8

Molecular formula:

C13H18O2

IUPAC Name:

2-[(4-tert-butylphenoxy)methyl]oxirane

Constituent 2

Reference substance name:

p-tert-butylphenyl-1-(2,3)-epoxypropyl ether

IUPAC Name:

p-tert-butylphenyl-1-(2,3)-epoxypropyl ether

Constituent 3

Reference substance name:

Oxirane, 2-((4-(1,1-dimethylethyl)phenoxy)methyl)-

IUPAC Name:

Oxirane, 2-((4-(1,1-dimethylethyl)phenoxy)methyl)-

Test material form:

other: Liquid at room temperature.

Details on test material:

As per IUCLID5 Sections 1.1. 1.2. and 4.1.

Test animals / tissue source

Species:

rabbit

Strain:

New Zealand White

Details on test animals or tissues and environmental conditions:

The rabbits were acquired from Rich-Gb II, mc; Wills Point, TX. The animals were housed in suspended, wire bottom, stainless steel cages,
1 per cage. The initial body weight of the animals placed on study was 2.40-2.975 kg. The animals were maintained in an animal room at a temperature of 19-20°C and a relative humidity of 45-92% with 12-hour light/dark cycle and 10-12 air changes/hour. The animals were offered PMI Feeds, Inc.TM Lab Rabbit Diet #532 ~8 oz. daily and Municipal water supply analyzed by TCEQ Water Utilities Division; available ad lilbitum from automatic water system.

Test system

Vehicle:

unchanged (no vehicle)

Controls:

not required

Amount / concentration applied:

0.1 mL

Duration of treatment / exposure:

72 hr

Observation period (in vivo):

72 hr

Number of animals or in vitro replicates:

3

Details on study design:

On Day0, a dose of 0.1 mL of the undiluted test substance was placed into the conjunctival sac of the right eye of each animal by gently pulling the lower lid away from the eyeball to form a cup into which the test substance was dropped. The lids were gently held together for one second to prevent loss of material. The untreated left eyes served as comparative controls.

Results and discussion

In vivo

Results

Irritation parameter:

overall irritation score

Basis:

mean

Time point:

other: 1, 24, 48 and 72 hr.

Score:

ca. 0

Max. score:

0

Reversibility:

other: Not applicable

Irritant / corrosive response data:

No evidence of irritation.

Applicant's summary and conclusion

Interpretation of results:

not irritating

Remarks:

Migrated information Criteria used for interpretation of results: expert judgment

Conclusions:

The test substance is not irritating to the rabbit eye under the cinditions of the study.

Executive summary:

In an O.E.C.D. 405 test guideline study the test substance, p-tert-butylphenyl-1 -(2,3 -epoxy)propyl ehter did not induce any evidence of eye irritation in the rabbit.