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Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: see 'Remark'
Remarks:
The studies performed in 1966 and 1967 are considered to be invalid since analytical data of the substance enriched air inhaled by the animals are missing. During the exposure time the volatile fraction of Antistatikum 743 evaporated and a solid residue remained. Therefore the concentration of Antistatikum 743 in the air was possibly not constant during the exposure time.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1966
Report Date:
1966

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: BASF internal standard test
Principles of method if other than guideline:
Method: BASF-Test: Test was performed in principle as described in OECD Guideline 403.
The test demonstrates the toxicity of an atmosphere saturated with vapours of the volatile components of a test substance at the temperature chosen for vapour generation (20 °C). 6 rats per sex were exposed to the vapours, generated by bubbling 200l/h air through a substance column of about 5 cm above a fritted glassdisc in a glass cylinder. The total exposure time was 8h. The documentation of clinical signs was performed over a period of 7 days after exposure with the test substance.
GLP compliance:
no
Test type:
other: inhalation hazard test

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
Name of the test substance used in the study report: Antistatikum 743
purity: no data
physical state: paste
It is not clear if the the production process of Antistatikum 743 [= Sulfonium compounds, C11-14-alkylbis(hydroxyethyl), 2-hydroxyethyl sulfates (salts)] changed in more than 30 years. Therefore it is assumed that the test itme in the studies performed between 1966 and 1971 may slightly differ from the current substance. Nevertheless, these well described studies performed according to internal standardised protocols are included into this data set since the changes of the test substance are assumed to be negligible.

Test animals

Species:
rat
Strain:
not specified
Sex:
male/female

Administration / exposure

Route of administration:
inhalation: vapour
Type of inhalation exposure:
not specified
Vehicle:
other: unchanged, no vehicle
Details on inhalation exposure:
The test demonstrates the toxicity of an atmosphere saturated with vapours of the volatile components of a test substance at the temperature chosen for vapour generation (20 °C). 6 rats per sex were exposed to the vapours, generated by bubbling 200l/h air through a substance column of about 5 cm above a fritted glassdisc in a glass cylinder. The total exposure time was 8h. The documentation of clinical signs was performed over a period of 7 days after exposure with the test substance.
Analytical verification of test atmosphere concentrations:
no
Duration of exposure:
8 h
Concentrations:
not determined
No. of animals per sex per dose:
6
Control animals:
no
Details on study design:
- Duration of observation period following administration: 7 days
- Frequency of observations: daily
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight
Statistics:
not applicable

Results and discussion

Effect levels
Sex:
male/female
Exp. duration:
8 h
Remarks on result:
other: no mortality observed
Mortality:
None
Clinical signs:
other: None
Body weight:
no data
Gross pathology:
no findings

Any other information on results incl. tables

No mortalities after 8-hour exposure to an atmosphere enriched with the  substance at 20°C.

Applicant's summary and conclusion

Executive summary:

No mortalities after 8-hour exposure to an atmosphere enriched with the  substance at 20°C.